Ignite Creation Date:
2024-05-06 @ 3:07 AM
Last Modification Date:
2024-10-26 @ 11:29 AM
Study NCT ID:
NCT02219035
Status:
UNKNOWN
Last Update Posted:
2014-08-18
First Post:
2014-08-15
Brief Title:
A Prospective Investigation of the VWF-ADAMTS 13 Axis in Acute Ischaemic Brain Injury TIAs and Stroke
Sponsor:
University College London
Organization:
University College London
Study Overview
Official Title:
A Prospective Investigation of the VWF-ADAMTS 13 Axis in Acute Ischaemic Brain Injury TIAs and Stroke
Status:
UNKNOWN
Status Verified Date:
2014-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In patients presenting with acute stroke or transient ischaemic attacks TIA von Willebrand factor related parameters including VWF antigen activity FVIIIc and propeptides ADAMTS13 levels and VWF multimers in cases where ADAMTS 13 was reduced will be measured Global haemostasis will be assessed using thrombin generation and the relation between increase thrombin generation and VWF explored Thrombin generation will be performed pre and post filtration for the presence of procoagulant microparticles These parameters will be investigated acutely at presentation and in convalescence in addition the effect on these parameters of treatment such as thrombolysis may be informative Correlation between measured parameters and adverse clinical outcome would be used to identify markers of severity and progression of ischaemic stroke and identification of potential novel approaches to therapy that might improve outcome
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None