Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00168649
Status:
UNKNOWN
Last Update Posted:
2013-11-15
First Post:
2005-09-12
Brief Title:
Vitamin A and Response to Endotoxin
Sponsor:
Bandim Health Project
Organization:
Bandim Health Project
Study Overview
Official Title:
The Effect of Vitamin A on the Response to Endotoxin
Status:
UNKNOWN
Status Verified Date:
2013-11
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans We furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses
Detailed Description:
Vitamin A given as treatment and pre-treatment has reduced the severity of symptoms after infusion with endotoxin in several animal models We intend to examine the effect of vitamin A as pre-treatment on the response to endotoxin in humans As studies in children in low-income countries have indicated that vitamin A has long-term effects on the immune system we furthermore wish to examine the long-term effects of vitamin A on the response to endotoxin This will be done in an established model using infusion with endotoxin to male human volunteers We hypothesise that vitamin A decreases endotoxin levels and TNF-alfa responses Furthermore we hypothesise that it reduces oxidative stress and injury
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 9583-2625 | None | None | None |