Ignite Creation Date:
2024-05-06 @ 3:07 AM
Last Modification Date:
2024-10-26 @ 11:28 AM
Study NCT ID:
NCT02201446
Status:
COMPLETED
Last Update Posted:
2017-02-17
First Post:
2014-07-24
Brief Title:
The Role of Circulating Soluble CD74 in Acute Lung Injury
Sponsor:
Changhai Hospital
Organization:
Changhai Hospital
Study Overview
Official Title:
Relationship Between Elevated Soluble Cluster of Differentiation 74 CD74 and Severity of Experimental and Clinical ALIARDS
Status:
COMPLETED
Status Verified Date:
2017-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Efforts to identify circulating factors that predict severity of acute lung injuryacute respiratory distress syndromeALIARDS patients is unrevealing The primary purpose of this study is to verify our hypothesis that soluble CD74 might be a potential novel ALIARDS biomarker
Detailed Description:
Acute lung injury ALI or acute respiratory distress syndrome ARDS is a devastating cause of morbidity and mortality characterized by alveolar epithelial and endothelial injury Despite recent advances in pathogenetic mechanisms and therapy strategies of ALI efforts to identify circulating factors that predict severity of ALIARDS patients have been unrevealing
CD74 also known as a major histocompatibility complex MHC class II invariant chain is a type II transmembrane protein recently found to be the high-affinity receptor of macrophage migration inhibitory factor MIF MIF promotes neutrophil accumulation in alveolar space via binding to CD74 expressed on the cell surface Our previous study consistent with others has shown that MIF was highly expressed in acute lung injury ALI In addition we also detected highly CD74 expression in lipopolysaccharide LPS-induced ALI mouse model Recently a circulating form of CD74 was discovered in autoimmune liver disease Similarly we investigated the existence of soluble form of CD74 in serum and bronchoalveolar lavage fluid BALF in ALI mouse model and burn or trauma related ALI patients Based on these finds we postulated that soluble CD74 might participate in regulating lung inflammation and be a potential novel ALIARDS biomarker
CD74 also known as a major histocompatibility complex MHC class II invariant chain is a type II transmembrane protein recently found to be the high-affinity receptor of macrophage migration inhibitory factor MIF MIF promotes neutrophil accumulation in alveolar space via binding to CD74 expressed on the cell surface Our previous study consistent with others has shown that MIF was highly expressed in acute lung injury ALI In addition we also detected highly CD74 expression in lipopolysaccharide LPS-induced ALI mouse model Recently a circulating form of CD74 was discovered in autoimmune liver disease Similarly we investigated the existence of soluble form of CD74 in serum and bronchoalveolar lavage fluid BALF in ALI mouse model and burn or trauma related ALI patients Based on these finds we postulated that soluble CD74 might participate in regulating lung inflammation and be a potential novel ALIARDS biomarker
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None