Ignite Creation Date:
2024-05-06 @ 3:07 AM
Last Modification Date:
2024-10-26 @ 11:28 AM
Study NCT ID:
NCT02204280
Status:
COMPLETED
Last Update Posted:
2015-07-21
First Post:
2014-07-23
Brief Title:
The Significance of Urine UbA52 In the Diagnosis of Diabetic Nephropathy
Sponsor:
Hebei Medical University Third Hospital
Organization:
Hebei Medical University Third Hospital
Study Overview
Official Title:
Urine UbA52 is a Biomarker of Early Diabetic Nephropathy
Status:
COMPLETED
Status Verified Date:
2014-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Definite diagnosis of diabetic nephropathy is currently based on renal biopsy findings In most cases however the diagnosis can be reliably made in patients with macroalbuminuria in the presence of diabetic retinopathyMicroalbuminuria is often used as a prognostic marker in type 1 diabetes because approximately 50 of type 1 diabetes patients with microalbuminuria will eventually develop diabetic nephropathy Conversely microalbu- minuria is of much less value as a marker in DM because it has a variety of causes including hypertension Thus additional markers are needed to identify patient groups with a high risk of developing overt diabetic nephropathy The aims of this study is checking urine UbA52 levels with ELISA to identify its significance in the diagnosis of diabetic nephropathy
Detailed Description:
It is now well recognized that the incidence of diabetes is increasing worldwide It is the leading cause of end-stage renal disease ESRD in Western countries Diabetic nephropathy has been reported to occur in 25-40 of people with diabetes The appearance of microalbuminuria usually is regarded as incipient nephropathy but recently work has suggested that some individuals with diabetes and decreased GFR may not have an increased urinary AERIdentification of markers for prediction of the clinical course of diabetic nephropathy remains a major challenge Previous research showed that mz14766 protein by mass spectrometry was selectively excreted in the urine of diabetic nephropathy patients the mz 14766 mass peaks were identified as UbA52 We suppose that UbA52 can be regard as a simple and practical biomarker for diagnosis of diabetic nephropathy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None