Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00167713
Status:
COMPLETED
Last Update Posted:
2005-09-21
First Post:
2005-09-11
Brief Title:
Treatment of Fever Due to Malaria With Ibuprofen
Sponsor:
Albert Schweitzer Hospital
Organization:
Albert Schweitzer Hospital
Study Overview
Official Title:
Randomised Double-Blind Placebo Controlled Study of the Antipyretic Effect of Ibuprofen in Children With Uncomplicated Malaria
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Drugs to treat fever are widely used in children with fever But there is a controversy about the benefit of reducing fever in children with malaria Ibuprofen is often used to treat malarial fever This study evaluates the capacity of ibuprofen to reduce fever in malaria The effect of ibuprofen on fever compared to only mechanical measures is investigated in children with malaria
Detailed Description:
Fever is the most apparent clinical manifestation of Plasmodium falciparum infection during the acute phase The role of fever in defence against malaria or in other infectious diseases remains unclear However it has been shown that febrile temperatures inhibit the growth of P falciparum in vitro
Antipyretic drugs are commonly and widely used to treat malarial fever in endemic areas There is however a controversy about the benefit of reducing fever in children with malaria Data from Gabon have revealed that neither paracetamol nor naproxen or metamizol - antipyretics often used in this area - had an effect on fever clearance time Worryingly paracetamol increased parasite-clearance times ie inhibited clearance of parasites and decreased significantly the production of oxygen radicals and tumour necrosis factor TNF mechanisms of the innate immune response pivotal to combat infections
Another antipyretic drug often used to treat malarial fever in endemic areas is ibuprofen However the rationale of its use and its capacity of reducing fever due to P falciparum infections has never been proven in this area
Comparison The effect of ibuprofen plus mechanical fever treatment continuous fanning tepid sponging and cooling blankets is compared to mechanical treatment alone to treat fever in children with malaria
Antipyretic drugs are commonly and widely used to treat malarial fever in endemic areas There is however a controversy about the benefit of reducing fever in children with malaria Data from Gabon have revealed that neither paracetamol nor naproxen or metamizol - antipyretics often used in this area - had an effect on fever clearance time Worryingly paracetamol increased parasite-clearance times ie inhibited clearance of parasites and decreased significantly the production of oxygen radicals and tumour necrosis factor TNF mechanisms of the innate immune response pivotal to combat infections
Another antipyretic drug often used to treat malarial fever in endemic areas is ibuprofen However the rationale of its use and its capacity of reducing fever due to P falciparum infections has never been proven in this area
Comparison The effect of ibuprofen plus mechanical fever treatment continuous fanning tepid sponging and cooling blankets is compared to mechanical treatment alone to treat fever in children with malaria
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None