Ignite Creation Date:
2024-05-06 @ 3:07 AM
Last Modification Date:
2024-10-26 @ 11:28 AM
Study NCT ID:
NCT02202148
Status:
COMPLETED
Last Update Posted:
2017-01-31
First Post:
2014-07-25
Brief Title:
Liver Stiffness Measurement in Alcohol-dependent Subjects in Relation to Abstinence After Withdrawal
Sponsor:
Centre Hospitalier Esquirol
Organization:
Centre Hospitalier Esquirol
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2017-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is complementary to the main study Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal NCT01491347
Liver stiffness variation is one of the major somatic effect of chronic alcohol consumption It is a consequence of numerous mechanisms including inflammation Liver stiffness seems to depend on alcohol consumption in alcohol dependent patient more precisely on the time after the last alcohol consumption This is very few documented after alcohol withdrawal and has never been explored during several months after withdrawal as a function of alcohol consumption and abstinence
Brain Derived neurotrophic Factor BDNF seems to play a major role in general homeostasis and also liver function
We propose here to analyse the serum BDNF levels variations after withdrawal according to liver stiffness levels and alcohol consumption status
We will also measure liver stiffness using Fibroscan in alcohol dependent subjects included in the main study to search for a link with serum BDNF levels and abstinence at day 0 14 28 and months 2 4 and 6
Liver stiffness variation is one of the major somatic effect of chronic alcohol consumption It is a consequence of numerous mechanisms including inflammation Liver stiffness seems to depend on alcohol consumption in alcohol dependent patient more precisely on the time after the last alcohol consumption This is very few documented after alcohol withdrawal and has never been explored during several months after withdrawal as a function of alcohol consumption and abstinence
Brain Derived neurotrophic Factor BDNF seems to play a major role in general homeostasis and also liver function
We propose here to analyse the serum BDNF levels variations after withdrawal according to liver stiffness levels and alcohol consumption status
We will also measure liver stiffness using Fibroscan in alcohol dependent subjects included in the main study to search for a link with serum BDNF levels and abstinence at day 0 14 28 and months 2 4 and 6
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None