Ignite Creation Date:
2024-05-06 @ 3:02 AM
Last Modification Date:
2024-10-26 @ 11:27 AM
Study NCT ID:
NCT02196220
Status:
COMPLETED
Last Update Posted:
2019-08-20
First Post:
2014-07-17
Brief Title:
Ultrasonographic Assessment of Carpal Tunnel Syndrome
Sponsor:
University of Utah
Organization:
University of Utah
Study Overview
Official Title:
Ultrasonographic Assessment of Carpal Tunnel Syndrome in Children With Mucopolysaccharidosis and Comparison to Median Nerve Anatomy in Healthy Children
Status:
COMPLETED
Status Verified Date:
2019-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Mucopolysaccharidosis are lysosomal storage disorders such as Hunter Hurler and Sanfilippo syndromes These patients have a genetic enzyme deficiency that results in the inability to degrade glycosaminoglycans The glycosaminoglycans accumulate in lysosomes causing cell enlargement and subsequent dysfunction The accumulation occurs in all tissues including cartilage joint capsule and tendons and can lead to carpal tunnel syndrome trigger digits and various other orthopaedic manifestations Van Heest White These children often suffer from severe cognitive impairment and are often unable to communicate pain or numbness Carpal tunnel syndrome is almost always present but may not become apparent until symptoms are severe and loss of function has occurred The current gold standard for diagnosis consists of electromyographic EMG and nerve conduction velocity NCV studies under sedation or general anesthetic Khanna
Primary Objective The investigators plan to correlate EMG findings and median nerve cross-sectional area in children with mucopolysaccharidosis The investigators hypothesis is that ultrasonography of the carpal tunnel in patients with mucopolysaccharidosis will prove to be an effective reliable and safe method to evaluate the median nerve thus avoiding the need for EMG studies and anesthesia
Secondary Objective The investigators want to determine the cross-sectional area of the median nerve using ultrasonography in a cohort of healthy children ages 3-12 The investigators plan to evaluate a cohort of healthy children to determine a normal cross-sectional area of the median nerve
Primary Objective The investigators plan to correlate EMG findings and median nerve cross-sectional area in children with mucopolysaccharidosis The investigators hypothesis is that ultrasonography of the carpal tunnel in patients with mucopolysaccharidosis will prove to be an effective reliable and safe method to evaluate the median nerve thus avoiding the need for EMG studies and anesthesia
Secondary Objective The investigators want to determine the cross-sectional area of the median nerve using ultrasonography in a cohort of healthy children ages 3-12 The investigators plan to evaluate a cohort of healthy children to determine a normal cross-sectional area of the median nerve
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None