Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00166738
Status:
UNKNOWN
Last Update Posted:
2007-08-24
First Post:
2005-09-11
Brief Title:
Analysis of Genomic DNA Alterations in Familial Schizophrenia
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Analysis of Genomic DNA Alterations in Familial Schizophrenia
Status:
UNKNOWN
Status Verified Date:
2005-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Persons with schizophrenia experience imaginary voices visions and disorganized thoughts and are handicapped when it comes to social life which is detrimental to the affected individuals and the community Although the pathogenesis of this mental disease has not been clearly elucidated much evidence suggests that inheritance is of major etiological importance and multiple genetic components are implicated Previous linkage studies of familial schizophrenia have led to the successful identification of numerous susceptibility loci covering many of the human chromosomes including chromosome 1q 5q 6p22 6p24 8q21 13q32 15q13-14 and 22q11 etc Necessities for further identification of candidate genes involved in familial schizophrenia by taking a genome-wide approach are listed as follows
1 given that multiple genes are responsible for this disease it is of critical interest to view the complete molecular profiling of schizophrenias genome
2 identification of promising schizophrenia candidate genes by genome-wide scanning will facilitate the development of molecular markers and provide a more objective and effective assessment method in psychotic diagnosis and prognosis
3 prevention of the onset of this disorder will be improved by early classification of individuals bearing strong genetic loading for schizophrenia as a high risk population
4 making a breakthrough into the investigation of schizophrenia pathogenesis by the characterization of susceptible genes found by genome-wide exploring
Array-based comparative genomic hybridization CGH allows high-throughput genome-wide survey for DNA copy number aberrations providing a powerful tool for investigating genetic disorders and for developing diagnostic and therapeutic targets Arrays used in this study consist of approximately 43000 60-mer oligonucleotide probes that span coding and noncoding regions of the whole human genome with an average spatial resolution of around 35 kb Furthermore the sensitivity of these arrays is capable of detecting and mapping regions of single-copy losses homozygous deletions and amplicons of various sizes even when using full-complexity genomic samples In this study the investigators will conduct an array-based comparative genomic hybridization CGH with genomic DNA of many affected members from schizophrenia families the investigators classified families according to the presence or absence of two or more affected members to identify a set of candidate genes associated with this disease It is hoped that the results obtained from this study will improve the accuracy and efficiency of psychotic treatment
1 given that multiple genes are responsible for this disease it is of critical interest to view the complete molecular profiling of schizophrenias genome
2 identification of promising schizophrenia candidate genes by genome-wide scanning will facilitate the development of molecular markers and provide a more objective and effective assessment method in psychotic diagnosis and prognosis
3 prevention of the onset of this disorder will be improved by early classification of individuals bearing strong genetic loading for schizophrenia as a high risk population
4 making a breakthrough into the investigation of schizophrenia pathogenesis by the characterization of susceptible genes found by genome-wide exploring
Array-based comparative genomic hybridization CGH allows high-throughput genome-wide survey for DNA copy number aberrations providing a powerful tool for investigating genetic disorders and for developing diagnostic and therapeutic targets Arrays used in this study consist of approximately 43000 60-mer oligonucleotide probes that span coding and noncoding regions of the whole human genome with an average spatial resolution of around 35 kb Furthermore the sensitivity of these arrays is capable of detecting and mapping regions of single-copy losses homozygous deletions and amplicons of various sizes even when using full-complexity genomic samples In this study the investigators will conduct an array-based comparative genomic hybridization CGH with genomic DNA of many affected members from schizophrenia families the investigators classified families according to the presence or absence of two or more affected members to identify a set of candidate genes associated with this disease It is hoped that the results obtained from this study will improve the accuracy and efficiency of psychotic treatment
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None