Ignite Creation Date:
2024-05-06 @ 3:01 AM
Last Modification Date:
2024-10-26 @ 11:27 AM
Study NCT ID:
NCT02186678
Status:
COMPLETED
Last Update Posted:
2023-04-06
First Post:
2014-06-04
Brief Title:
Comparison of Diagnostic Performances of 68Ga-DOTATATE PET-CT and 18F-FDOPA PET-CT in Paragangliomas and Pheochromocytomas Evaluation
Sponsor:
Assistance Publique Hopitaux De Marseille
Organization:
Assistance Publique Hopitaux De Marseille
Study Overview
Official Title:
Comparison of Diagnostic Performances of 68Ga-DOTATATE PET-CT and 18F-FDOPA PET-CT in Paragangliomas and Pheochromocytomas Evaluation Monocentric Prospective Study
Status:
COMPLETED
Status Verified Date:
2023-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DOTATATE
Brief Summary:
18F-FDOPA PET-CT is currently the gold standard in the evaluation of Pheochromocytomas and Paragangliomas PHEO - PGL since these tumors can also decarboxylate amino acids such as dihydroxyphenylalanine DOPA This property is common to tumors of the APUD system Amine Precursor Uptake and Decarboxylation In recent years PET Positron Emission Tomography imaging using peptide receptors has gained an increasing role in the management of NETs The use of somatostatin agonists radiolabeled with gallium-68 68Ga enables targeting of Somatostatin receptors SSTRs with a PET resolution This has improved diagnosis of SSTRs-expressing tumors including PGLs
In the present study the investigators have chosen DOTATATE Nal3-octreotate rather than other agonists DOTATOC and DOTANOC because of its higher affinity for SST2 which is the most overexpressed subtype in PHEOPGL However performances of 18F-FDOPA PET-CT and 68Ga-DOTATATE PET-CT have never been compared in this clinical setting
In the present study the investigators have chosen DOTATATE Nal3-octreotate rather than other agonists DOTATOC and DOTANOC because of its higher affinity for SST2 which is the most overexpressed subtype in PHEOPGL However performances of 18F-FDOPA PET-CT and 68Ga-DOTATATE PET-CT have never been compared in this clinical setting
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None