Ignite Creation Date:
2024-05-06 @ 3:01 AM
Last Modification Date:
2024-10-26 @ 11:27 AM
Study NCT ID:
NCT02183753
Status:
COMPLETED
Last Update Posted:
2015-06-11
First Post:
2014-06-03
Brief Title:
Effects of Wood Smoke Particles on Influenza-induced Nasal Inflammation in Normal Volunteers
Sponsor:
University of North Carolina Chapel Hill
Organization:
University of North Carolina Chapel Hill
Study Overview
Official Title:
Effects of Wood Smoke Particles on Influenza-induced Nasal Inflammation in Normal Volunteers
Status:
COMPLETED
Status Verified Date:
2015-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
Woodsies
Brief Summary:
This study is focused on the pathophysiology underlying the association between exposure to particulate pollutants and risk forresponse to viral infection The investigators hypothesize that exposure to wood smoke particles WSP enhances influenza virus-induced granulocyte and NK cell activation via hyaluronic acid-mediated effects on IFNg production Oxidant stress and viral replication may also be affected As an NIH funded ViCTER project the purpose of the study is also to test novel assays of granulocyte activation Doershuk lab and lipid mediator activation Albritton lab which have not previously been used in this type of research
Healthy nonsmoking adults age 18-40 years will be recruited This is a randomized placebo controlled study comparing NLF granulocyte responses to LAIV administered after either WSP or clean air in normal healthy volunteers Subjects receive either WSP or placebo clean air followed by a standardized dose of LAIV and serial post-infection sampling of nasal lavage fluids nasal biopsy and blood
Healthy nonsmoking adults age 18-40 years will be recruited This is a randomized placebo controlled study comparing NLF granulocyte responses to LAIV administered after either WSP or clean air in normal healthy volunteers Subjects receive either WSP or placebo clean air followed by a standardized dose of LAIV and serial post-infection sampling of nasal lavage fluids nasal biopsy and blood
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5R01ES013611-09 | NIH | None | httpsreporternihgovquickSearch5R01ES013611-09 |