Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00161161
Status:
COMPLETED
Last Update Posted:
2005-12-30
First Post:
2005-09-08
Brief Title:
Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder
Sponsor:
UMC Utrecht
Organization:
UMC Utrecht
Study Overview
Official Title:
Genetic Liability in the Brain Morphology of Attention Deficit Hyperactivity Disorder
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Attention Deficit Hyperactivity Disorder ADHD is a heritable psychiatric disorder with onset in childhood Twin and adoption studies indicate that additive genetic factors explain up to 80 of the variance underlying susceptibility The siblings of children with ADHD have a three- to fivefold increased risk of having ADHD compared to the siblings of healthy control subjects and the risk is even greater for monozygotic twins with 50-80 concordance compared with up to 33 in dizygotic twins As full siblings share on average 50 of their genes even the unaffected siblings of children with ADHD would be expected to share some of the genes involved in the disorder The neuroanatomical substrate of ADHD is becoming increasingly better defined by a growing body of evidence from imaging studies Evidence from neuroimaging studies suggests that this disorder is associated with reductions in brain volume up to 5 in these children In this protocol we collected MRI-scans from boys with ADHD and their unaffected siblings as well as control subjects In addition cheekswabs were later collected for DNA analysis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None