Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00162409
Status:
UNKNOWN
Last Update Posted:
2008-10-29
First Post:
2005-09-11
Brief Title:
Relationship Between Folic Acid and Warfarin Metabolism and Effect
Sponsor:
Hadassah Medical Organization
Organization:
Hadassah Medical Organization
Study Overview
Official Title:
The Effect of Folic Acid Concentration and Folic Acid Supplementation on Warfarin Pharmacokinetic and Warfarin Dose Requirement at Steady State
Status:
UNKNOWN
Status Verified Date:
2008-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Folic acid supplementation has been shown previously to be associated with enhanced formation of p-HPPH from phenytoin a metabolic pathway which is predominantly mediated through the activity of CYP2C9
The metabolism of S warfarin the more active enantiomer of warfarin is also mediated predominantly through the activity of CYP2C9
The purpose of the present study was to examine the relationship between folic acid concentration and warfarin pharmacokinetic as well as warfarin dose requirement among patients treated by warfarin In addition the effect of folic acid supplementation 5 mgd for 3 weeks on warfarin pharmacokinetic and warfarin dose requirement will be evaluated in the second part of the study
The metabolism of S warfarin the more active enantiomer of warfarin is also mediated predominantly through the activity of CYP2C9
The purpose of the present study was to examine the relationship between folic acid concentration and warfarin pharmacokinetic as well as warfarin dose requirement among patients treated by warfarin In addition the effect of folic acid supplementation 5 mgd for 3 weeks on warfarin pharmacokinetic and warfarin dose requirement will be evaluated in the second part of the study
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None