Ignite Creation Date:
2024-05-05 @ 11:54 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00168506
Status:
UNKNOWN
Last Update Posted:
2007-04-05
First Post:
2005-09-10
Brief Title:
Panic Disorder and Cardiac Risk
Sponsor:
Baker Heart Research Institute
Organization:
Baker Heart Research Institute
Study Overview
Official Title:
Panic Disorder and Cardiac Risk Evaluation of a Psychological Treatment Which Addresses Biology Psychology and Behaviour
Status:
UNKNOWN
Status Verified Date:
2007-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The reason for increased cardiac mortality in panic disorder has not been precisely identified but possibly is due to chronic activation of the cardiac stimulant sympathetic nerves which may predispose the individual with panic disorder to disorders of cardiac rhythm and coronary artery spasm The uniqueness of this study lies in its comprehensive evaluation of a psychobiological approach to the treatment of panic disorder using change in biological behavioural and psychological variables as criteria for efficacy 50 patients aged between 18 and 60 years will be recruited both males and females They will be treated with either cognitive behavioural therapy CBT or SSRI selective serotonin re-uptake inhibitor antidepressants or a combination of both
This project will firstly compare individuals with panic disorder who demonstrate abnormal brain transmitter noradrenaline serotonin with those who demonstrate normal activity of these neurotransmitters on interoceptive accuracy for changes in sympathetic nervous system arousal It is predicted that individuals who demonstrate abnormal activity of these neurotransmitters will also demonstrate enhanced interoceptive ability to detect changes in arousal levels Secondly this project will evaluate the effects of a psychobiological treatment approach to panic disorder involving a combination of CBT and SSRI This approach will be compared to the effects of both these interventions alone on a comprehensive array of measures related to panic disorder It is predicted that the combined approach will be the most effective intervention on behavioural psychological and biological variables and cardiac risk We will also be able to assess whether changes in panic disorder severity are associated with changes in interoceptive accuracy
This project will firstly compare individuals with panic disorder who demonstrate abnormal brain transmitter noradrenaline serotonin with those who demonstrate normal activity of these neurotransmitters on interoceptive accuracy for changes in sympathetic nervous system arousal It is predicted that individuals who demonstrate abnormal activity of these neurotransmitters will also demonstrate enhanced interoceptive ability to detect changes in arousal levels Secondly this project will evaluate the effects of a psychobiological treatment approach to panic disorder involving a combination of CBT and SSRI This approach will be compared to the effects of both these interventions alone on a comprehensive array of measures related to panic disorder It is predicted that the combined approach will be the most effective intervention on behavioural psychological and biological variables and cardiac risk We will also be able to assess whether changes in panic disorder severity are associated with changes in interoceptive accuracy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None