Ignite Creation Date:
2024-05-06 @ 3:00 AM
Last Modification Date:
2024-10-26 @ 11:26 AM
Study NCT ID:
NCT02175251
Status:
COMPLETED
Last Update Posted:
2023-09-08
First Post:
2014-05-22
Brief Title:
Low and High Frequency Repetitive Transcranial Magnetic Stimulation rTMS in the Treatment of Resistant Auditory Hallucination in Schizophrenia
Sponsor:
Assistance Publique - Hôpitaux de Paris
Organization:
Assistance Publique - Hôpitaux de Paris
Study Overview
Official Title:
Low and High Frequency Repetitive Transcranial Magnetic Stimulation rTMS in the Treatment of Resistant Auditory Hallucination in Schizophrenia a Double Blind Sham-controlled Randomised Study
Status:
COMPLETED
Status Verified Date:
2023-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
rTMS
Brief Summary:
Auditory Hallucinations AH are experienced by 50 to 70 of subjects with schizophrenia Almost a quarter of patients are medication resistant to such symptoms The application of rTMS at low frequency in the left temporoparietal cortex reduces AH A pilot study reported successful treatment of AH with high frequency rTMS rTMS 20Hz should be a shorter and an easier treatment for out-patients with schizophrenia compared to low stimulation treatment
Detailed Description:
90 schizophrenia patients Diagnostic and Statistical Manual of Mental Disorders 4th Edition Text Revision DSM IV-TR criteria with persistent Auditory Hallucinations AH resistant to antipsychotic treatments will be recruited A double blind sham-controlled randomized parallel study comparing three groups treated 10 session in 5 days with high frequency 20 Hz low frequency 1Hz and sham-controlled condition rTMS They will be followed 3 month and evaluated using Auditive Hallucination Rating Scale AHRS Scale for the Assessment of Positive Symptoms Scores SAPS Scale for the Assessment of Negative Symptoms Scores SANS and Positive And Negative Symptom Scale PANSS global score and Global Assessment of Functioning GAF score
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| IDRCB 2013-A00872-43 | OTHER | FRENCH AUTHORITY | None |