Ignite Creation Date:
2024-05-06 @ 2:58 AM
Last Modification Date:
2024-10-26 @ 11:26 AM
Study NCT ID:
NCT02173925
Status:
COMPLETED
Last Update Posted:
2015-01-07
First Post:
2014-06-13
Brief Title:
Gut Hormone Nociceptors Neurotrophic Factors Expression in Functional Dyspepsia
Sponsor:
Seoul National University Bundang Hospital
Organization:
Seoul National University Bundang Hospital
Study Overview
Official Title:
Ghrelin Leptin Serotonin TRPV1 NGF and GDNF Expression in the Patients With Functional Dyspepsia
Status:
COMPLETED
Status Verified Date:
2015-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FD
Brief Summary:
The pathophysiology of functional dyspepsia is still unclear but several peptides have been indicated in the etiological factors in FD Ghrelin and leptin are involved in regulation of appetite and gut motility and serotonin is a typical neurotransmitter related with sensory and motor functions of gut On the other hand transient receptor potential vanilloid receptor 1 TRPV1 has been proposed to be involved with functional gastrointestinal disorder and expression of this receptor could be regulated by nerve growth factor NGF or glial cell-line derived neurotrophic factor GDNF The investigators aimed to determine whether expressions of ghrelinleptin serotoninTRPV1GDNF and NGF in blood or gastric mucosa of FD patients are different from those in healthy controls and whether some changes of their expression correlate with certain dyspeptic symptoms The investigators also investigated the effect of H pylori infection by comparing their expressions before and one year after H pylori eradication
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None