Ignite Creation Date:
2024-05-06 @ 2:57 AM
Last Modification Date:
2024-10-26 @ 11:26 AM
Study NCT ID:
NCT02168218
Status:
COMPLETED
Last Update Posted:
2018-05-04
First Post:
2014-06-05
Brief Title:
Effects of Milk Proteins on Protein Synthesis in Healthy Male Subjects Fed a Hypercaloric High Sucrose Diet
Sponsor:
University of Lausanne
Organization:
University of Lausanne
Study Overview
Official Title:
Effects of Milk Proteins on Whole Body Protein Synthesis and Ectopic Lipid Deposition During Sucrose Overfeeding in Healthy Male Subjects
Status:
COMPLETED
Status Verified Date:
2018-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
FruMilk
Brief Summary:
This study aims at assessing the hypothesis that dietary protein content is a major factor regulating lean body mass gain and energy expenditure during overfeeding and thus long term body weight gain
To test this hypothesis healthy normal weight male and female subjects will before and after a 7-day hypercaloric high-sucrose diet 40 excess energy as sucrose and either a low 5 total energy or a high 20 total energy protein intake Each subject will be studied with both low- and high protein diets according to a randomized crossover study On each occasion the following measurements will be done in basal conditions after 2-day isoenergetic controled diet and at the end of the 7-day overfeeding
whole-body protein turnover oxidation and synthesis in fasting conditions and fed conditions 13C-labelled leucine
intrahepatic and intramuscular fat concentration 1H-Magnetic Resonance Spectroscopy
Energy metabolism in fasted and fed conditions indirect calorimetry
plasma concentration of glucose non-esterified fatty acids total triglyceride very-low density lipoprotein VLDL-triglyceride insulin glucagon growth hormone GH insulin-like growth factor 1 IGF1 insulin-like growth factor binding protein IGFBP 12 and 3 in fasting and fed conditions The effects of high-protein and low-protein sucrose overfeeding on whole body protein synthesis will be compared using two-way ANOVA relationships between changes in whole body protein synthesis on one hand and intrahepaticintramuscular fat concentrations total energy expenditure and plasma concentration of metabolic variables on the other hand will be evaluated by linear regression analysis
To test this hypothesis healthy normal weight male and female subjects will before and after a 7-day hypercaloric high-sucrose diet 40 excess energy as sucrose and either a low 5 total energy or a high 20 total energy protein intake Each subject will be studied with both low- and high protein diets according to a randomized crossover study On each occasion the following measurements will be done in basal conditions after 2-day isoenergetic controled diet and at the end of the 7-day overfeeding
whole-body protein turnover oxidation and synthesis in fasting conditions and fed conditions 13C-labelled leucine
intrahepatic and intramuscular fat concentration 1H-Magnetic Resonance Spectroscopy
Energy metabolism in fasted and fed conditions indirect calorimetry
plasma concentration of glucose non-esterified fatty acids total triglyceride very-low density lipoprotein VLDL-triglyceride insulin glucagon growth hormone GH insulin-like growth factor 1 IGF1 insulin-like growth factor binding protein IGFBP 12 and 3 in fasting and fed conditions The effects of high-protein and low-protein sucrose overfeeding on whole body protein synthesis will be compared using two-way ANOVA relationships between changes in whole body protein synthesis on one hand and intrahepaticintramuscular fat concentrations total energy expenditure and plasma concentration of metabolic variables on the other hand will be evaluated by linear regression analysis
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None