Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00168207
Status:
COMPLETED
Last Update Posted:
2012-01-20
First Post:
2005-09-09
Brief Title:
IL-7 Receptor Polymorphisms and Immune Recovery With HAART
Sponsor:
The Alfred
Organization:
The Alfred
Study Overview
Official Title:
The Relationship of Single Nucleotide Polymorphisms in the Interleukin-7 Receptor-α Gene to CD4 Immune Recovery in HIV Infected Patients Who Begin Antiretroviral Treatment With HAART
Status:
COMPLETED
Status Verified Date:
2012-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim is to investigate the hypothesis that IL7-receptor polymorphisms contribute to the differential immune recovery of CD4 T cells following HAART
Detailed Description:
AIM To examine the association between the four haplotypes of IL-7Rα gene and a cohort of HIV infected patients who have commenced HAART with varying CD4 T lymphocyte responses
METHODS IL-7Rα gene SNPs and haplotypes will be measured by constructing DNA pools and PCR amplification and DNA sequencing IL-7Rα expression will be examined using constitutive expression of IL-7Rα IL-7Rα gene expression and inducible expression of IL7Rα
METHODS IL-7Rα gene SNPs and haplotypes will be measured by constructing DNA pools and PCR amplification and DNA sequencing IL-7Rα expression will be examined using constitutive expression of IL-7Rα IL-7Rα gene expression and inducible expression of IL7Rα
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None