Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00161135
Status:
COMPLETED
Last Update Posted:
2007-04-20
First Post:
2005-09-08
Brief Title:
Magnetic Resonance Imaging in Children and Adolescents With Autism and Multiple Complex Developmental Disorders
Sponsor:
UMC Utrecht
Organization:
UMC Utrecht
Study Overview
Official Title:
Magnetic Resonance Imaging in Children and Adolescents With Autism and Multiple Complex Developmental Disorders
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study aims to investigate the overlap and differences between autism and MCDD as neuropsychiatric childhood disorders MRI scans are acquired from subjects with autism subjects with a diagnosis of MCDD and typically developing controls Volumetric measure of various brain regions are compared between groups We hypothesize that subjects with autism will have larger brains than controls whereas subjects with MCDD will have smaller brains
Detailed Description:
Autism and Childhood-onset Schizophrenia have been clearly defined as neuropsychiatric disorders since the studies of Kolvin and Rutter In the early seventies the discussion on a possible overlap between the two types of disorders vanished but nowadays this issue revives Amongst all the advances of the DSM diagnostic criteria the omission of developmental information appears to be a disadvantage The Pervasive Developmental Spectrum is a broad spectrum that with exceptions for Autism and some other characteristic disorders to a large extent consists of an ill-defined restcategory Most patients actually belong to this last category the so-called PDD-NOS group In recent years more has been published about the subgroups within this large group One of these subgroups the Multiple Complex Developmental Disorder MCDD appears to be a well defined category of patients whose validity has been confirmed by research In adulthood a large percentage of this MCDD group seems to develop Schizophrenia or a Schizophrenia related disorder This again does arise the question of a possible overlap This discussion is even emphasized by reports notably on -mostly retrospective- studies of premorbid autistic features in patients with Schizophrenia
In the present day studies on neurodevelopmental psychiatric disorders there is a search for biological markers or discriminating factors One of the applied methods is structural imaging Question marks can be placed on the differing study set-ups and protocols which seriously hinder their inter alia comparison However one can still conclude that the results of studies on subjects with Autism and Childhood-onset Schizophrenia reveal major differences However structural abnormalities do not tell anything about possible functional abnormalities But detecting structural abnormalities can be helpful in forming hypothesis about the origin of these neurodevelopmental disorders
In this study brain structures will be measured by magnetic resonance imaging Structural deviances will be interpreted as a reflection of functional abnormalities It is hypothesized that the abnormalities on structural imaging in MCDD patients will more resemble the abnormalities found in the literature for Childhood-onset Schizophrenia instead of the deviances revealed in subjects with Autism
In this study patients with Autism and MCDD will be divided in two groups before and after puberty Each group will behold 15-40 subjects They each will be compared with two groups of 20-25 age sex and IQ matched controls They will participate in carrying out a MRI scan filling in some questionnaires and if necessary an IQ test and a general physical examinationThe MRI scans will be measured and compared with each other in order to find disorder-specific abnormalities
In the present day studies on neurodevelopmental psychiatric disorders there is a search for biological markers or discriminating factors One of the applied methods is structural imaging Question marks can be placed on the differing study set-ups and protocols which seriously hinder their inter alia comparison However one can still conclude that the results of studies on subjects with Autism and Childhood-onset Schizophrenia reveal major differences However structural abnormalities do not tell anything about possible functional abnormalities But detecting structural abnormalities can be helpful in forming hypothesis about the origin of these neurodevelopmental disorders
In this study brain structures will be measured by magnetic resonance imaging Structural deviances will be interpreted as a reflection of functional abnormalities It is hypothesized that the abnormalities on structural imaging in MCDD patients will more resemble the abnormalities found in the literature for Childhood-onset Schizophrenia instead of the deviances revealed in subjects with Autism
In this study patients with Autism and MCDD will be divided in two groups before and after puberty Each group will behold 15-40 subjects They each will be compared with two groups of 20-25 age sex and IQ matched controls They will participate in carrying out a MRI scan filling in some questionnaires and if necessary an IQ test and a general physical examinationThe MRI scans will be measured and compared with each other in order to find disorder-specific abnormalities
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None