Ignite Creation Date:
2024-05-06 @ 2:53 AM
Last Modification Date:
2024-10-26 @ 11:25 AM
Study NCT ID:
NCT02153255
Status:
WITHDRAWN
Last Update Posted:
2016-07-28
First Post:
2014-05-28
Brief Title:
Dynamic Gait Analysis in Children With Mucopolysaccharidosis Type IVa
Sponsor:
Birmingham Womens and Childrens NHS Foundation Trust
Organization:
Birmingham Womens and Childrens NHS Foundation Trust
Study Overview
Official Title:
None
Status:
WITHDRAWN
Status Verified Date:
2016-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Closure of Gait Analysis Laboratory - unable to set up alternative gait laboratory in time for funders
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Mucopolysaccharidosis Type IVa MPS IVa Morquio Disease is a rare inherited lysosomal storage disorder caused by deficiency of the enzyme galactose-6-sulfatase
Children with this disease accumulate a chemical called keratan sulphate which stops their skeletons developing properly They are very short in stature and many of their joints are unstable Children with MPS IVa walk in a different way to other people due to a combination of lax ligaments and skeletal problems such as knock-knees
Human walking involves the coordinated movements of all four limbs As we walk the arms swing oppositely to the legs This movement pattern is very different in children with MPS IVa This change seems to involve the whole musculoskeletal system and depends on the severity of the disease
Recent studies in children with MPS IVa describing walking pattern have concentrated solely on the lower or upper limb respectively and have not looked at the interaction of the upper and lower limbs during walking
To our knowledge the mechanics of walking in children with MPS IVa has not been investigated using a dynamic gait analysis tool using cameras sensors and electrodes to track the movements of different parts of the body during walking and we aim to characterise this in a small number of children with MPS IVa and also examine the effects of splinting the wrist upon the walking pattern to see if this simple intervention makes it easier or more difficult for children with MPS IVa to walk
Children with this disease accumulate a chemical called keratan sulphate which stops their skeletons developing properly They are very short in stature and many of their joints are unstable Children with MPS IVa walk in a different way to other people due to a combination of lax ligaments and skeletal problems such as knock-knees
Human walking involves the coordinated movements of all four limbs As we walk the arms swing oppositely to the legs This movement pattern is very different in children with MPS IVa This change seems to involve the whole musculoskeletal system and depends on the severity of the disease
Recent studies in children with MPS IVa describing walking pattern have concentrated solely on the lower or upper limb respectively and have not looked at the interaction of the upper and lower limbs during walking
To our knowledge the mechanics of walking in children with MPS IVa has not been investigated using a dynamic gait analysis tool using cameras sensors and electrodes to track the movements of different parts of the body during walking and we aim to characterise this in a small number of children with MPS IVa and also examine the effects of splinting the wrist upon the walking pattern to see if this simple intervention makes it easier or more difficult for children with MPS IVa to walk
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None