Ignite Creation Date:
2024-05-06 @ 2:53 AM
Last Modification Date:
2024-10-26 @ 11:25 AM
Study NCT ID:
NCT02153957
Status:
COMPLETED
Last Update Posted:
2024-06-28
First Post:
2014-05-31
Brief Title:
Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors
Sponsor:
National Cancer Institute NCI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
A Randomized Controlled Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors
Status:
COMPLETED
Status Verified Date:
2024-10-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
- More children with cancer are surviving into adulthood Some side effects from treatment go away quickly But some problems may not go away or may only show up months or years later These problems are called late effects Late effects can cause difficulties in cognitive functions such as attention and memory Physical activity has been found to improve the attention and memory skills of children with Attention Deficit Hyperactivity Disorder ADHD Researchers want to see if physical activity can help with these cognitive problems in children with brain tumors
Objectives
- To see if physical activity can improve cognitive functions in children who had radiation therapy for a brain tumor
Eligibility
- Children ages 8 17 who had radiation for a brain tumor at least 2 years ago They must have access to a computer
Design
Participants will be screened with height weight and medical history They will answer questions about daily physical activities Their heart will be checked
Participants will go to the clinic for 2 days They will have a fitness exam and tests about attention memory and concentration They will have blood taken and answer questions Parents will also answer questions
Participants will be put into 2 groups For the first 12 weeks the intervention group will follow a physical activity program The control group will do their usual physical activities
For the second 12 weeks the control group will follow the physical activity program The intervention group will continue the activities on their own All groups will track their physical activity with an activity monitor and computer
Participants will have a follow-up visit at the clinic after each session They will repeat some of the tests listed above
The study lasts 24 weeks plus the two follow-up visits Participants can keep their activity monitor
- More children with cancer are surviving into adulthood Some side effects from treatment go away quickly But some problems may not go away or may only show up months or years later These problems are called late effects Late effects can cause difficulties in cognitive functions such as attention and memory Physical activity has been found to improve the attention and memory skills of children with Attention Deficit Hyperactivity Disorder ADHD Researchers want to see if physical activity can help with these cognitive problems in children with brain tumors
Objectives
- To see if physical activity can improve cognitive functions in children who had radiation therapy for a brain tumor
Eligibility
- Children ages 8 17 who had radiation for a brain tumor at least 2 years ago They must have access to a computer
Design
Participants will be screened with height weight and medical history They will answer questions about daily physical activities Their heart will be checked
Participants will go to the clinic for 2 days They will have a fitness exam and tests about attention memory and concentration They will have blood taken and answer questions Parents will also answer questions
Participants will be put into 2 groups For the first 12 weeks the intervention group will follow a physical activity program The control group will do their usual physical activities
For the second 12 weeks the control group will follow the physical activity program The intervention group will continue the activities on their own All groups will track their physical activity with an activity monitor and computer
Participants will have a follow-up visit at the clinic after each session They will repeat some of the tests listed above
The study lasts 24 weeks plus the two follow-up visits Participants can keep their activity monitor
Detailed Description:
BACKGROUND
Children treated with cranial radiation therapy CRT for brain tumors are at high risk for developing neurocognitive late effects consisting of significant declines in overall IQ and specific cognitive impairments particularly in attention memory and processing speed Academic functioning daily activities and quality of life QOL also are impacted and children often require special educational services
Despite adaptations in radiation therapy delay of radiation reduced dose specialized techniques cognitive deficits still develop Interventions targeting cognitive rehabilitation are limited yet sorely needed
A potential and novel intervention for cognitive rehabilitation that has not been explored in children with cancer involves physical activity PA Compelling evidence from both human and animal studies indicates that PA affects the same brain mechanisms and cognitive functions damaged by CRT and chemotherapy
Previous PA intervention studies in children with cancer have been found to be feasible safe and beneficial to health but have not examined cognition outcomes Therefore we will conduct a randomized controlled trial to evaluate the effects of PA on the cognitive functioning of children treated with CRT for brain tumors In addition we will enhance the intervention by combining it with Acceptance and Commitment Therapy ACT techniques to maximize participants motivation to engage in PA
The immediate intervention group the intervention group will engage in the enhanced PA intervention program for the first 12 weeks followed by 12 weeks of PA maintenance on their own while the delayed intervention control group the control group will engage in their usual physical activity for the first 12 weeks followed by the enhanced PA intervention program for the second 12 weeks
OBJECTIVES
-To assess the effects of a 12-week enhanced physical activity PA home intervention on visual memory CogState One Card Learning Accuracy score in children treated with CRT for brain tumors compared to a control group engaged in usual physical activity during the first 12 weeks
ELIGIBILITY
Children ages 8 - 18 years previously diagnosed with a brain tumor in childhood who are at least 1 year post-completion of CRT and who are not on an active anti-tumor treatment will be eligible
Children should have reported or documented cognitive difficulties in attention learning and memory or processing speed per the child s parent or legal guardian
DESIGN
-In this prospective randomized controlled trial Children will be randomized to one of two groups Group 1 n30 The immediate intervention group the intervention group will participate in the enhanced PA home intervention group for the first 12 weeks followed by 12 weeks of PA maintenance on their own
Group 2 n30 The delayed intervention control group the control group will engage in their usual physical activity no intervention for 12 weeks followed by the enhanced PA home intervention for 12 weeks
Neurobehavioral circulating growth factors and cardiorespiratory evaluations will be conducted at baseline T0 and after the first 12 weeks at home T2 in both the intervention and control groups The acute effects of the in-lab PA will be assessed immediately following the baseline treadmill fitness test T1 using selected cognitive measures in both groups PA for both groups will be measured throughout the period at home via activity monitors
After the completion of the first 12 week period at home and the follow-up evaluations T2 the intervention group will be asked to maintain their PA levels on their own for the next 12 weeks while the control group will participate in the enhanced PA intervention at home for 12 weeks A final cognitive evaluation will be conducted in both groups after the completion of the second 12- week period T3 The primary outcome measure is the Cogstate One Card Learning Accuracy Score The effects of PA on other neurobehavioral outcomes and circulating growth factors also will be examined
Children treated with cranial radiation therapy CRT for brain tumors are at high risk for developing neurocognitive late effects consisting of significant declines in overall IQ and specific cognitive impairments particularly in attention memory and processing speed Academic functioning daily activities and quality of life QOL also are impacted and children often require special educational services
Despite adaptations in radiation therapy delay of radiation reduced dose specialized techniques cognitive deficits still develop Interventions targeting cognitive rehabilitation are limited yet sorely needed
A potential and novel intervention for cognitive rehabilitation that has not been explored in children with cancer involves physical activity PA Compelling evidence from both human and animal studies indicates that PA affects the same brain mechanisms and cognitive functions damaged by CRT and chemotherapy
Previous PA intervention studies in children with cancer have been found to be feasible safe and beneficial to health but have not examined cognition outcomes Therefore we will conduct a randomized controlled trial to evaluate the effects of PA on the cognitive functioning of children treated with CRT for brain tumors In addition we will enhance the intervention by combining it with Acceptance and Commitment Therapy ACT techniques to maximize participants motivation to engage in PA
The immediate intervention group the intervention group will engage in the enhanced PA intervention program for the first 12 weeks followed by 12 weeks of PA maintenance on their own while the delayed intervention control group the control group will engage in their usual physical activity for the first 12 weeks followed by the enhanced PA intervention program for the second 12 weeks
OBJECTIVES
-To assess the effects of a 12-week enhanced physical activity PA home intervention on visual memory CogState One Card Learning Accuracy score in children treated with CRT for brain tumors compared to a control group engaged in usual physical activity during the first 12 weeks
ELIGIBILITY
Children ages 8 - 18 years previously diagnosed with a brain tumor in childhood who are at least 1 year post-completion of CRT and who are not on an active anti-tumor treatment will be eligible
Children should have reported or documented cognitive difficulties in attention learning and memory or processing speed per the child s parent or legal guardian
DESIGN
-In this prospective randomized controlled trial Children will be randomized to one of two groups Group 1 n30 The immediate intervention group the intervention group will participate in the enhanced PA home intervention group for the first 12 weeks followed by 12 weeks of PA maintenance on their own
Group 2 n30 The delayed intervention control group the control group will engage in their usual physical activity no intervention for 12 weeks followed by the enhanced PA home intervention for 12 weeks
Neurobehavioral circulating growth factors and cardiorespiratory evaluations will be conducted at baseline T0 and after the first 12 weeks at home T2 in both the intervention and control groups The acute effects of the in-lab PA will be assessed immediately following the baseline treadmill fitness test T1 using selected cognitive measures in both groups PA for both groups will be measured throughout the period at home via activity monitors
After the completion of the first 12 week period at home and the follow-up evaluations T2 the intervention group will be asked to maintain their PA levels on their own for the next 12 weeks while the control group will participate in the enhanced PA intervention at home for 12 weeks A final cognitive evaluation will be conducted in both groups after the completion of the second 12- week period T3 The primary outcome measure is the Cogstate One Card Learning Accuracy Score The effects of PA on other neurobehavioral outcomes and circulating growth factors also will be examined
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 14-C-0116 | None | None | None |