Ignite Creation Date:
2024-05-06 @ 2:53 AM
Last Modification Date:
2024-10-26 @ 11:25 AM
Study NCT ID:
NCT02150330
Status:
COMPLETED
Last Update Posted:
2014-05-29
First Post:
2014-05-26
Brief Title:
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Sponsor:
Taipei Veterans General Hospital Taiwan
Organization:
Taipei Veterans General Hospital Taiwan
Study Overview
Official Title:
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Status:
COMPLETED
Status Verified Date:
2014-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Diminished ovarian reserve DOR is one the challenge in the field of artificial reproductive technology ART while there is still no effective resolution of this disorder In patents with DOR the pregnancy rate is about only 2-4 Eventually patients with DOR turn to adapt children instead In recent studies dehydroepiandrosterone DHEAS supplement might play a role in reverse diminished ovarian reserve and improve the prognosis of ART Cumulus cells formed cumulus-oocyte complex COC with oocyte play a important role in folliculogenesis oocyte maturation oocyte meiosis and ovulation Growing evidences disclose there are crosstalks between oocyte and cumulus cells as paracrine regulations Aberration the crosswalks between oocytes and cumulus cells would be associated with poor prognosis of folliculogenesis and further pregnancy outcomes In patients under ovarian hyper-stimulation protocol the assessment of cumulus cells might be reliable indicators of folliculogenesis embryo development pregnancy rate and pregnancy outcomes These genes indicators such as Hyaluronan synthaseHAS2 Versican VCAN Thrombospondin 1 THBS1 Runt-related transcription factor 2 RUNX2 Chromobox homolog 3 CBX3Tripartite motif-containing 28 TRIM28 B-cell lymphoma 2 BCL2BCL2-associated X protein BAX This study was assess the gene expressions of cumulus cells after the DHEAS supplement in patients with DOR under ovarian hyper stimulation protocol
Detailed Description:
This study was designed as a prospective case-control study to assess the gene expression of cumulus cells after DHEAS supplement Patients with diminished ovarian reserve under ovarian hyper-stimulation protocol were evaluated at Kaoshiung Veteran General Hospital from January 1 2013 through October 31 2013 Approval for the study was obtained from the hospitals ethic committee and informed consent was obtained from all patients VGHKS13-CT11-17
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None