Ignite Creation Date:
2024-05-06 @ 2:52 AM
Last Modification Date:
2024-10-26 @ 11:25 AM
Study NCT ID:
NCT02148692
Status:
COMPLETED
Last Update Posted:
2019-01-03
First Post:
2014-05-23
Brief Title:
Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients
Sponsor:
Technische Universität Dresden
Organization:
Technische Universität Dresden
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2019-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
PROBESE
Brief Summary:
Postoperative respiratory failure particularly after surgery under general anesthesia adds to the morbidity and mortality of surgical patients Anesthesiologists inconsistently use positive end-expiratory pressure PEEP and recruitment maneuvers in the hope that this may improve oxygenation and protect against postoperative pulmonary complications PPCs especially in obese patients While anesthesiologists tend to use PEEP higher than in non-obese patients While it is uncertain whether a strategy that uses higher levels of PEEP with recruitment maneuvers truly prevents PPCs in these patients use of higher levels of PEEP with recruitment maneuvers could compromise intra-operative hemodynamics
The investigators aim to compare a ventilation strategy using higher levels of PEEP with recruitment maneuvers with one using lower levels of PEEP without recruitment maneuvers in obese patients at an intermediate-to-high risk for PPCs
We hypothesize that an intra-operative ventilation strategy using higher levels of PEEP and recruitment maneuvers as compared to ventilation with lower levels of PEEP without recruitment maneuvers prevents PPCs in obese patients at an intermediate-to-high risk for PPC
The investigators aim to compare a ventilation strategy using higher levels of PEEP with recruitment maneuvers with one using lower levels of PEEP without recruitment maneuvers in obese patients at an intermediate-to-high risk for PPCs
We hypothesize that an intra-operative ventilation strategy using higher levels of PEEP and recruitment maneuvers as compared to ventilation with lower levels of PEEP without recruitment maneuvers prevents PPCs in obese patients at an intermediate-to-high risk for PPC
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None