Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00160888
Status:
UNKNOWN
Last Update Posted:
2005-09-12
First Post:
2005-09-08
Brief Title:
Vasoreactivity in Carriers of Genetic Polymorphisms
Sponsor:
Heidelberg University
Organization:
Heidelberg University
Study Overview
Official Title:
Endothelium-Dependent Vasoreactivity in Nitric Oxide Synthase Gene Glu298Asp Polymorphism Studies in Healthy Volunteers
Status:
UNKNOWN
Status Verified Date:
2005-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The objective of the study is to assess the impact of genetic variation especially polymorphisms of the gene coding endothelial nitric oxide synthase eNOS and the bradykinin B2 receptor gene on venous and arterial responsiveness to vasodilators in healthy individuals without cardiovascular risk factors
Detailed Description:
Study I Using the dorsal hand vein compliance technique dose-response curves to bradykinin and sodium nitroprusside will be obtained in healthy volunteers during preconstriction with phenylephrine and after pretreatment with a single dose of 500 mg iv acetylsalicylic acid
Study II Using venous occlusion plethysmography dose-response curves to acetylcholine sodium nitroprusside and L-NG-monomethyl-arginine L-NMMA will be obtained in healthy volunteers pretreated with a single dose of 500mg iv acetylsalicylic acid
Study II Using venous occlusion plethysmography dose-response curves to acetylcholine sodium nitroprusside and L-NG-monomethyl-arginine L-NMMA will be obtained in healthy volunteers pretreated with a single dose of 500mg iv acetylsalicylic acid
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None