Ignite Creation Date:
2024-05-06 @ 2:50 AM
Last Modification Date:
2024-10-26 @ 11:23 AM
Study NCT ID:
NCT02130791
Status:
COMPLETED
Last Update Posted:
2015-12-02
First Post:
2014-04-29
Brief Title:
Phenotypic and Genotypic Markers of Performance Vulnerability to Sleep Loss
Sponsor:
University of Pennsylvania
Organization:
University of Pennsylvania
Study Overview
Official Title:
Phenotypic and Genotypic Markers of Performance Vulnerability to Sleep Loss
Status:
COMPLETED
Status Verified Date:
2015-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Insufficient sleep is common affecting 20-40 of adults and resulting from sleep disorders medical conditions work demands stressemotional distress and socialdomestic responsibilities It produces significant social financial and health-related costs and it has increasingly become a major public health concern as population studies worldwide have found that reduced sleep duration is associated with increased risks of obesity morbidity and mortality It is well established that sleep loss causes fatigue and sleepiness as well as errors and accidents that are due to its adverse neurobehavioral effects on alertness mood and cognitive functions However there are substantial trait-like differences among people in the extent to which they experience such neurobehavioral deficits when sleep deprived Common genetic variations involved in sleep-wake circadian and cognitive regulation may underlie these large inter-individual differences in neurobehavioral vulnerability to sleep deprivation though it remains unclear whether different types of sleep deprivation involve the same phenotypic responses and same genotypic contributors This project will be the first large-scale investigation of markers of differential cognitive vulnerability to both acute total sleep loss and chronic partial sleep loss It will identify individuals who are at significant risk for fatigue and severe impairments from sleep loss A total of 110 healthy adults will undergo a 13-day laboratory protocol to thoroughly characterize their cognitive psychological and physiological responses to two of the most common forms of sleep loss--acute total sleep deprivation 1 night of sleep loss and chronic partial sleep deprivation 5 nights of sleep limited to 4 hr The findings from this study will represent a critical first step toward tailoring appropriate follow-up interventions for sleep loss and its symptomatic relief by finding predictors of at-risk individuals who should avoid sleep loss whenever possible andor seek effective countermeasures Whether or not markers of neurobehavioral vulnerability to sleep loss are identified the results of the project will help inform public policies pertaining to the need for adequate sleep and for countermeasures for sleep loss and also will further our understanding and management of vulnerability to excessive sleepiness due to common sleep and medical disorders
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None