Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00161057
Status:
COMPLETED
Last Update Posted:
2009-04-23
First Post:
2005-09-08
Brief Title:
Functional Brain Activation Patterns in Schizophrenia Measured Before and After Treatment
Sponsor:
UMC Utrecht
Organization:
UMC Utrecht
Study Overview
Official Title:
Functional Brain Activation Patterns in Schizophrenia Measured Before and After Treatment
Status:
COMPLETED
Status Verified Date:
2009-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study we the investigators at UMC Utrecht intend to investigate changes in brain activation patterns using functional magnetic resonance imaging MRI in patients suffering from schizophrenia who are medication naive or off medication before using medication and after 8 weeks of medication Patients will perform a working memory task a language task and a motor task while lying in the scanner We hypothesize that the efficiency of the working memory system is reduced and that the lateralization of language is diminished in these patients and that these functions will normalize after treatment
Detailed Description:
Schizophrenia is a heterogeneous disorder with a wide range of symptoms and signs including hallucinations delusions disorganisation negative symptoms and cognitive deficits Investigation of the neural substrates of the cognitive deficits in schizophrenia has revealed abnormalities in brain activity patterns Particularly earlier studies using functional FMRI conducted at the UMCU revealed diminished language laterality deficits in working memory and a reduced ability to automate cognitive processes The aim of this project is to study the relationship between these brain activation patterns and neuroleptic treatment More insight into psychopharmacological effects on brain physiology may eventually enable us to better predict what effect treatment will have on patients
Patients with a confirmed diagnosis of schizophrenia schizophreniform disorder schizoaffective disorder or psychotic disorder not otherwise specified NOS who are medication naive or medication free for a period of at least 2 weeks will be included Patients will be tested before and after 8 weeks of treatment with an atypical antipsychotic In the scanner patients will perform a working memory task a language task and a visual-motor task At study entry and after 8 weeks the PANSS Clinical Global Impressions CGI and CDSS Calgary Depression Scale of Schizophrenia will be performed Besides these patients we will also include a group of matched healthy controls We hypothesize that in medication naive or patients of-medication lateralization is reduced and that efficiency of the working memory system is reduced Lateralization is expected to correlate negatively with positive functions We expect that antipsychotic treatment will normalize brain function and that the degree of normalization is correlated with the clinical measures of treatment efficacy
Patients with a confirmed diagnosis of schizophrenia schizophreniform disorder schizoaffective disorder or psychotic disorder not otherwise specified NOS who are medication naive or medication free for a period of at least 2 weeks will be included Patients will be tested before and after 8 weeks of treatment with an atypical antipsychotic In the scanner patients will perform a working memory task a language task and a visual-motor task At study entry and after 8 weeks the PANSS Clinical Global Impressions CGI and CDSS Calgary Depression Scale of Schizophrenia will be performed Besides these patients we will also include a group of matched healthy controls We hypothesize that in medication naive or patients of-medication lateralization is reduced and that efficiency of the working memory system is reduced Lateralization is expected to correlate negatively with positive functions We expect that antipsychotic treatment will normalize brain function and that the degree of normalization is correlated with the clinical measures of treatment efficacy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None