Ignite Creation Date:
2024-05-06 @ 2:48 AM
Last Modification Date:
2024-10-26 @ 11:24 AM
Study NCT ID:
NCT02137421
Status:
COMPLETED
Last Update Posted:
2017-05-02
First Post:
2014-05-09
Brief Title:
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome
Sponsor:
Tehran University of Medical Sciences
Organization:
Tehran University of Medical Sciences
Study Overview
Official Title:
Effects of Resveratrol on Crosstalk Between Canonical β-cateninWnt and FOXO Pathways in Coronary Artery Disease Patients With Metabolic Syndrome A Case Control Study
Status:
COMPLETED
Status Verified Date:
2014-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this study is to explore the role of Canonical β-cateninWnt and forkhead box O FOXO pathways by means of investigating their target genes in coronary artery disease CAD pathogenesis and to examine the effects of resveratrol RES on these pathways in CAD patients
Detailed Description:
Metabolic syndrome is a constellation of cardiovascular and metabolic risk factors including obesity insulin resistance hypertension and dyslipidemia Coronary artery disease CAD is considerably linked with these risk factors Oxidative stress has a major role in development of atherosclerosis that is believed as the most common pathologic process underlying CAD The up-regulated gene-expression of free radical scavenging enzymes such as manganese superoxide dismutase MnSOD by members of the forkhead box O FOXO transcription factors is considered to be one of the paramount cell defensive mechanisms against oxidative damage It is now well recognized that β-catenin binds to FOXOs during oxidative stress and acts as the pivotal mediator in canonical Wnt signaling so that it translocates to the nucleus and interacts with the family of transcription factors T-cell factorlymphoid enhancer factor TCFLEF to regulate the expression of Wnt target genes Recent evidence suggested that the canonical Wnt signaling plays a profound role in regulation of lipid metabolism and glucose homeostasis Peroxisome proliferator-activated receptor delta PPAR-δ is one of the Wnt target genes which is believed to be operative in cardiometabolic protection Interestingly it has been demonstrated that impaired Wnt signaling pathway is contributed to inflammation foam cell formation and endothelial dysfunction which are recognized as atherosclerosis pathogenic factors Resveratrol RES 3 4 5 trihydroxystilbene a natural polyphenol with antioxidant effects can be found in red grapes and its processed drinks eg red wine peanuts pomegranates and mulberriesIncreasing body of evidence suggest a protective role for RES against CAD however the underlying mechanisms still remain to be elucidated We perform this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched men with 40-55 years old healthy subjects as controls The effects of RES on β-Catenin manganese superoxide dismutase MnSOD and peroxisome proliferator-activated receptor delta PPAR-δ expression are evaluated in peripheral blood mononuclear cells PBMCs of participants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None