Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00160368
Status:
UNKNOWN
Last Update Posted:
2007-04-25
First Post:
2005-09-08
Brief Title:
Effects of Potassium Salts on Blood Pressure and Target Organ Damage
Sponsor:
St Georges University of London
Organization:
St Georges University of London
Study Overview
Official Title:
Effect of Potassium Bicarbonate and Potassium Chloride on Blood Pressure and Markers of Target Organ Damage in Hypertensives
Status:
UNKNOWN
Status Verified Date:
2007-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the effect of potassium chloride and potassium bicarbonate on blood pressure and also to determine whether increasing potassium intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease as well as on bone health
Detailed Description:
Randomised trials have shown that increasing potassium intake lowers blood pressure However most previous trials used potassium chloride Whereas potassium in fruits and vegetables is not a chloride salt but a mixture of potassium phosphate sulphate citrate and many organic anions most of which are precursors of potassium bicarbonate It is unclear whether non-chloride salt of potassium has greater or lesser effect on blood pressure compared to potassium chloride
Experimental studies in animals and epidemiological studies in humans suggest that a high potassium intake may have beneficial effects on the cardiovascular system and the kidney independent of its effect on blood pressure and also reduce the risk of osteoporosis
We propose to carry out a randomised double-blind trial to compare potassium bicarbonate with potassium chloride looking at their effect on blood pressure and also to determine whether these potassium salts have beneficial effects on the cardiovascular system kidney and bone health
Comparisons potassium chloride vs potassium bicarbonate vs placebo
Experimental studies in animals and epidemiological studies in humans suggest that a high potassium intake may have beneficial effects on the cardiovascular system and the kidney independent of its effect on blood pressure and also reduce the risk of osteoporosis
We propose to carry out a randomised double-blind trial to compare potassium bicarbonate with potassium chloride looking at their effect on blood pressure and also to determine whether these potassium salts have beneficial effects on the cardiovascular system kidney and bone health
Comparisons potassium chloride vs potassium bicarbonate vs placebo
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None