Ignite Creation Date:
2024-05-06 @ 2:46 AM
Last Modification Date:
2024-10-26 @ 11:23 AM
Study NCT ID:
NCT02124109
Status:
COMPLETED
Last Update Posted:
2020-02-13
First Post:
2014-04-25
Brief Title:
The Genetic Basis of Acquired Heart Disease in Africa
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Genetic Basis of Acquired Heart Disease in Africa
Status:
COMPLETED
Status Verified Date:
2020-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Background
- An acquired heart disease is one that a person gets after they are born Two of these are rheumatic heart disease RHD and endomyocardial fibrosis EMF They are found more commonly in people who live in Africa than in other places in the world Researchers want to learn more about these diseases They especially want to know what role genes and other factors play in them
Objective
- To identify genetic risk factors for RHD and EMF in sub-Saharan Africa
Eligibility
Children and adults with RHD or EMF
Healthy volunteers over age 10
Design
Participants will come from existing study groups in Uganda and Nigeria
Participants may be required to provide a sample of their DNA They will do this with either a blood or saliva sample or a swab of the mouth
Collected samples will be labeled with a code and sent to a lab in the United States for analysis Remaining portions of participants samples will be stored for an unlimited period of time They may be used in future studies
Some genetic and health information from participants might be placed into one or more scientific databases
Participant names and identifying information will be kept private But there is a small chance someone could trace them from their genetic information
- An acquired heart disease is one that a person gets after they are born Two of these are rheumatic heart disease RHD and endomyocardial fibrosis EMF They are found more commonly in people who live in Africa than in other places in the world Researchers want to learn more about these diseases They especially want to know what role genes and other factors play in them
Objective
- To identify genetic risk factors for RHD and EMF in sub-Saharan Africa
Eligibility
Children and adults with RHD or EMF
Healthy volunteers over age 10
Design
Participants will come from existing study groups in Uganda and Nigeria
Participants may be required to provide a sample of their DNA They will do this with either a blood or saliva sample or a swab of the mouth
Collected samples will be labeled with a code and sent to a lab in the United States for analysis Remaining portions of participants samples will be stored for an unlimited period of time They may be used in future studies
Some genetic and health information from participants might be placed into one or more scientific databases
Participant names and identifying information will be kept private But there is a small chance someone could trace them from their genetic information
Detailed Description:
Recent advances in genomic techniques are making possible a new wave of genetic discovery in many complex diseases However the genetic risk factors for two forms of acquired heart disease that are particularly common in Africa - rheumatic heart disease RHD and endomyocardial fibrosis EMF remains unknown In this application we propose to evaluate genetic risk factors for rheumatic heart disease RHD and endomyocardial fibrosis EMF A number of factors should facilitate the identification of genetic risk variants underlying the two conditions First both forms of acquired heart disease are endemic to sub-Saharan Africa SSA Second affected patients and those who do not develop the conditions share a common environment Finally the availability of high density SNP arrays to capture common and rare variation makes the characterization of genomic variation better than ever Patients will be enrolled at the Uganda Heart Institute in Kampala Uganda and at the College of Medicine University of Lagos Nigeria with the potential to include other African sites Genomic studies will be done at the NIH
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 14-HG-N098 | None | None | None |