Ignite Creation Date:
2024-05-06 @ 2:46 AM
Last Modification Date:
2024-10-26 @ 11:23 AM
Study NCT ID:
NCT02127125
Status:
COMPLETED
Last Update Posted:
2020-09-11
First Post:
2014-04-24
Brief Title:
Mechanism of Microbiome-induced Insulin Resistance in Humans Aim2
Sponsor:
The University of Texas Health Science Center at San Antonio
Organization:
The University of Texas Health Science Center at San Antonio
Study Overview
Official Title:
Mechanism of Microbiome-induced Insulin Resistance in Humans Aim2
Status:
COMPLETED
Status Verified Date:
2020-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MicroB2
Brief Summary:
The purpose of this study is to determine whether microbiome modulation and an experimental reduction in plasma LPS concentration improve inflammation and insulin action in insulin resistant obese and T2DM subjects
Detailed Description:
In this Aim we will test the hypothesis that lowering lipopolysaccharide LPS concentration in the circulation will improve systemic muscle inflammation and glucose metabolism in insulin resistant obese and T2DM subjects by protecting the intestinal barrier with a synbiotic Bifidobacterium longum R0175 and oligofructose or by sequestering LPS in the gastrointestinal lumen with sevelamer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None