Ignite Creation Date:
2024-05-05 @ 11:53 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00167024
Status:
UNKNOWN
Last Update Posted:
2005-11-28
First Post:
2005-09-12
Brief Title:
Application of Genetic Polymorphisms of DNA Repair in The Prediction of Prostate Cancer Susceptibility and Its Clinical Outcome
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2005-03
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Primary to investigate the effects of DNA repair gene polymorphisms on prostate cancer susceptibility pathological grade disease stage and clinical outcome Secondary to understand the association between DNA repair gene polymorphism and prostate cancer and provided important information for screening prevention and treatment of prostate cancer
Detailed Description:
DNA repair plays a key role in carcinogenesis through the removal and repair of DNA damage induced by endogenous and environmental sources The DNA repair system included four pathways 1 Base Excision Repair BER 2 Nucleotide Excision Repair NER 3 Mismatch Repair MMR and 4 Double-Strand Break Repair including homologous recombination pathway and nonhomologous end-joining repair pathway Decreased and impaired DNA repair capacity has been reported in various cancers however its effect on prostate cancer still under investigated
Common polymorphisms in DNA repair gene may alter protein function and individuals capacity to repair damaged DNA hence influence the cancer susceptibility Polymorphic variants of DNA repair gene have been found to be associated with cancer susceptibility but rare studies have investigated their effect on prostate cancer Since variation in the function of these DNA repair genes also impact a cancer cells viability or resistance to treatment genetic variants in DNA repair might serve as a valuable biomarker in forcasting the result of cancer treatment In fact some reports have demonstrated the association between polymorphisms of DNA repair genes and results of treatment of various cancers
For the present study proposal we focused on several DNA repair genes X-ray repair cross- complementing group 1 XRCC1 human oxoguanine glycosylase I hOGG1 xeroderma pigmentosum complementation group D XPD hMSH2 hMLH1 and X-ray repair cross-complementing group 3 XRCC3 which might have relevance in prostate carcinogenesis based on their known functions XRCC1 is involved in DNA repair in the base excision pathway the hOGG1 gene encodes a DNA glycosylase apurinic-apyrimidinic lyase that catalyzes the excision and removal the 8-OH-dG 8-hydroxy- 2-deoxyguanine - which is a major form of oxidative DNA damage The XPD gene codes for a DNA helicase involved in transcription and nucleotide excision repair The hMSH2 and hMLH1 are genes involved with mismatch repair The XRCC3 gene encoded a protein in the double-strand break homologous recombinational repair pathways
In this proposed study we will also use PCR-based methods to investigate the effects of DNA repair gene polymorphisms on prostate cancer susceptibility pathological grade disease stage and clinical outcome With these efforts we will further understand the association between DNA repair gene polymorphism and prostate cancer and provided important information for screening prevention and treatment of prostate cancer
Common polymorphisms in DNA repair gene may alter protein function and individuals capacity to repair damaged DNA hence influence the cancer susceptibility Polymorphic variants of DNA repair gene have been found to be associated with cancer susceptibility but rare studies have investigated their effect on prostate cancer Since variation in the function of these DNA repair genes also impact a cancer cells viability or resistance to treatment genetic variants in DNA repair might serve as a valuable biomarker in forcasting the result of cancer treatment In fact some reports have demonstrated the association between polymorphisms of DNA repair genes and results of treatment of various cancers
For the present study proposal we focused on several DNA repair genes X-ray repair cross- complementing group 1 XRCC1 human oxoguanine glycosylase I hOGG1 xeroderma pigmentosum complementation group D XPD hMSH2 hMLH1 and X-ray repair cross-complementing group 3 XRCC3 which might have relevance in prostate carcinogenesis based on their known functions XRCC1 is involved in DNA repair in the base excision pathway the hOGG1 gene encodes a DNA glycosylase apurinic-apyrimidinic lyase that catalyzes the excision and removal the 8-OH-dG 8-hydroxy- 2-deoxyguanine - which is a major form of oxidative DNA damage The XPD gene codes for a DNA helicase involved in transcription and nucleotide excision repair The hMSH2 and hMLH1 are genes involved with mismatch repair The XRCC3 gene encoded a protein in the double-strand break homologous recombinational repair pathways
In this proposed study we will also use PCR-based methods to investigate the effects of DNA repair gene polymorphisms on prostate cancer susceptibility pathological grade disease stage and clinical outcome With these efforts we will further understand the association between DNA repair gene polymorphism and prostate cancer and provided important information for screening prevention and treatment of prostate cancer
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None