Ignite Creation Date:
2024-05-06 @ 2:45 AM
Last Modification Date:
2024-10-26 @ 11:22 AM
Study NCT ID:
NCT02114216
Status:
COMPLETED
Last Update Posted:
2016-05-02
First Post:
2014-03-23
Brief Title:
Nociceptors Neurotrophic Factors and Cytokine Expression in Gastroesophageal Reflux Disease
Sponsor:
Seoul National University Bundang Hospital
Organization:
Seoul National University Bundang Hospital
Study Overview
Official Title:
Symptomatic Gastroesophageal Reflux Disease is Associated With Increased TRPV1 and PAR2 mRNA Expression Levels in the Esophageal Mucosa
Status:
COMPLETED
Status Verified Date:
2016-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Transient receptor potential vanilloid-1 TRPV1 receptor and proteinase-activated receptor 2 PAR2 have been implicated in the mechanism of acid induced inflammation in gastroesophageal reflux disease GERD We aimed to evaluate TRPV1 and PAR2 mRNA expression levels in the GERD patients and their relationship with endoscopic findings and reflux symptoms
Detailed Description:
All the subjects receive upper GI endoscopy and completed questionnaires about GERD symptoms under the supervision of a well-trained interviewer Subjects are excluded if there was a history of gastrointestinal surgery Barretts esophagus esophageal motility disorder duodenal ulcer benign gastric ulcer or gastroduodenal cancer and if he or she had any history of systemic disease requiring chronic medication except for hypertension and diabetes mellitus
The subjects are classified into 3 groups after upper GI endoscopy and completing questionnaires about GERDsymptoms ERDerosive reflux disease NERDnonerosive reflux disease and control group
The subjects are classified into 3 groups after upper GI endoscopy and completing questionnaires about GERDsymptoms ERDerosive reflux disease NERDnonerosive reflux disease and control group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None