Ignite Creation Date:
2024-05-06 @ 2:44 AM
Last Modification Date:
2024-10-26 @ 11:23 AM
Study NCT ID:
NCT02118545
Status:
COMPLETED
Last Update Posted:
2016-03-08
First Post:
2014-04-15
Brief Title:
Von Willebrand Factor to Predict Postoperative Outcome
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Preoperative Von Willebrand Factor to Predict Postoperative Liver Dysfunction and Morbidity After Liver Resection
Status:
COMPLETED
Status Verified Date:
2015-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation Endothelial cell dysfunction as well as platelet activation often occur in liver disease and portal hypertension which may lead to an increase in circulating vWF levels Indeed multiple studies have reported that liver disease is associated with increased circulating vWF- antigen vWF-Ag Furthermore increased circulating vWF -Ag Levels have been shown to be associated with increased mortality rates in patients with chronic liver disease Within a prospective evaluation cohort the investigators were able to document that patients with increased vWF-Ag levels prior to liver resection suffered from an increased incidence of postoperative liver dysfunction and morbidity Within this prospective multicenter validation study the investigators now aim to prospectively validate that circulating vWF-Ag prior to liver resection is a valuable marker to predict postoperative clinical outcome
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None