Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00155571
Status:
COMPLETED
Last Update Posted:
2005-11-28
First Post:
2005-09-09
Brief Title:
The Occurrence of Periopathogens in Betel-Nut Chewers and the Effects of Areca-Nut on Periopathogens
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
The Occurrence of Periopathogens in Betel-Nut Chewers and the Effects of Areca-Nut on Periopathogens
Status:
COMPLETED
Status Verified Date:
2001-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Periodontal disease is considered to be an infection disease Recent evidence supported the role of smoking as a potent risk factor for the development of periodontal disease However the effect of another oral habit betel quid chewing on periodontal tissues has not been well determined The purpose of the present study is to analysis the role of bacteria on the periodontium in the betel quid chewers Plaque samples will be collected from betel quid chewers and the occurrence of periodotopathogens will be analyzed Since most chewers also smokers plaque samples from age matched smokers but not betel chewers and non-smokers will analysis for comparison An in vitro test is also performed to evaluate whether the extract has a direct inhibitory effect on common periodontal pathogens such as Porphyromoans gingivalis Bacteroides forsythus Actinobacillus actinomycetemcomitans
Detailed Description:
Periodontal disease is considered to be an infection disease Specific microorganisms especially the gram-negative anaerobic bacteria gain predominance in periodontal pockets and challenge the host Lipopolysaccharides of the bacteria and other virulence factors will interact with macrophages and active cells to synthesis large quantities of IL-1 TNF PgE2 and matrix metalloproteinases and lead to the degradation of the collagen and bone destruction It has been shown that the genetic or environmental factors can modulate the initiation and progression of periodontal disease Recent evidence supported the role of smoking as a potent risk factor for the development of periodontal disease However the effect of another oral habit betel quid chewing on periodontal tissues has not been well determined Earlier epidemiological studies have shown a detrimental effect on periodontal tissues Higher prevalence of periodontal disease among betel chewers than among non-chewers was found even when subgroups of similar oral hygiene were compared In vitro studies also support the nut extract has a cytopathologic effects on gingival fibroblast The extract or the major betel nut alkaloid arecoline can inhibit the growth attachment and matrix protein synthesis of gingival fibroblast Study also showed that ripe and tender extract can reduce the antibacterial activity of neutrophils in vitro However most earlier epidemiological studies did not adjust the potentially confounding variables such as age socioeconomic status oral hygiene Besides most chewers are also smokers and drinkers whether the higher periodontal index may contribute from the smoking habit or betel quid chewing or the combination of both habits cannot be determined Conversely it is also found that the betel nut has an antibacterial properties and prolonged exposure can suppress the salivary organisms It is also used for treating bleeding gums in ancient Indian medicine Inhibitory effect on Streptococcus mutans Streptococcus salivarius Fusbobacerium nucleatum was shown but there are no any data concerning the effect on the periodontal pathogens Since the challenge of the bacteria is essential to initiate the disease process the presence of more virulence types of plaque bacteria may increase the risk and the rate of progression of periodontal disease It is not known whether the extract can affect the composition of the dental plaque through changing the oral ecology such as the pH value of the saliva a direct inhibitory effect on the periodontal microorganism or through inhibiting the colonization of the Streptococcus and then prevent the further succession of another bacterial complex The purpose of the present study is to analysis the role of bacteria on the periodontium in the betel quid chewers Plaque samples will be collected from betel quid chewers and the occurrence of periodotopathogens will be analyzed Since most chewers also smokers plaque samples from age matched smokers but not betel chewers and non-smokers will analysis for comparison An in vitro test is also performed to evaluate whether the extract has a direct inhibitory effect on common periodontal pathogens such as Porphyromoans gingivalis Bacteroides forsythus Actinobacillus actinomycetemcomitans
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NSC-90-2314-B-002-357 | None | None | None |