Ignite Creation Date:
2024-05-05 @ 10:17 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005337
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Hostility and Coronary Risk--Role of Weak Vagal Function
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine whether deficient vagal antagonism of sympathetic nervous system SNS actions on the heart contributed to increased coronary heart disease risk in hostile persons
Detailed Description:
DESIGN NARRATIVE
Sophisticated electrophysiologic monitoring approaches were used to 1 show greater sensitivity in nonhostile young men to T-wave attenuation effects of isoproterenol infusion following vagal blockade 2 show that vagal enhancement reduced and shortened the T-wave attenuation effects of isoproterenol infusion more in hostile young men 3 evaluate these effects of vagal blockage and enhancement in middle-aged men and in young and middle-aged women and 4 relate the T-wave effects in these studies to other measures of vagal tone and other biobehavioral mechanisms of coronary-prone behavior
Four studies were conducted in normal young and middle-aged men and women selected as high and low on hostility evaluating vagal tone measures and effects of isoproterenol infusion on EKG T-wave and ST response after pretreatment with saline neostigmine and atropine Demonstration that hostility was associated with deficient vagal anatagonism of SNS effects on the heart especially in middle-aged as compared to younger persons suggested that diminished vagal tone was one pathway whereby high hostility contributed to increased CHD risk Clinical studies were then conducted to determine whether weaker vagal tone predicted increased myocardial ischemia andor poorer outcomes in coronary heart disease patients
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Sophisticated electrophysiologic monitoring approaches were used to 1 show greater sensitivity in nonhostile young men to T-wave attenuation effects of isoproterenol infusion following vagal blockade 2 show that vagal enhancement reduced and shortened the T-wave attenuation effects of isoproterenol infusion more in hostile young men 3 evaluate these effects of vagal blockage and enhancement in middle-aged men and in young and middle-aged women and 4 relate the T-wave effects in these studies to other measures of vagal tone and other biobehavioral mechanisms of coronary-prone behavior
Four studies were conducted in normal young and middle-aged men and women selected as high and low on hostility evaluating vagal tone measures and effects of isoproterenol infusion on EKG T-wave and ST response after pretreatment with saline neostigmine and atropine Demonstration that hostility was associated with deficient vagal anatagonism of SNS effects on the heart especially in middle-aged as compared to younger persons suggested that diminished vagal tone was one pathway whereby high hostility contributed to increased CHD risk Clinical studies were then conducted to determine whether weaker vagal tone predicted increased myocardial ischemia andor poorer outcomes in coronary heart disease patients
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL044998 | NIH | None | httpsreporternihgovquickSearchR01HL044998 |