Ignite Creation Date:
2024-05-06 @ 2:42 AM
Last Modification Date:
2024-10-26 @ 11:22 AM
Study NCT ID:
NCT02101814
Status:
UNKNOWN
Last Update Posted:
2014-04-14
First Post:
2014-03-26
Brief Title:
Energy Balance and Inflammation in Obese Adults Bariatric Surgery Follow-up
Sponsor:
Federal University of São Paulo
Organization:
Federal University of São Paulo
Study Overview
Official Title:
Analysis of Neuroendocrine Regulation of Balance Energy and Inflammatory Factors in Obese Adults Submitted to Bariatric Surgery
Status:
UNKNOWN
Status Verified Date:
2014-04
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The prevalence of obesity is steadily growing in many parts of the world in order to reach epidemic proportions Changes in signaling pathways state of hunger and satiety contribute to the increase in obesity and metabolic syndrome Currently the white adipose tissue also is considered a secretory tissue by producing numerous adipokines involved in a chronic state of inflammation which may interfere with the neuroendocrine regulation of energy balance that affect the weight loss process The bariatric surgery is recommended as the most effective tool in the treatment and control of morbid obesity The study population will consist of patients undergoing bariatric surgery of type Roux-en-Y gastric bypass The study was performed in Clinical Hospital of the Federal University of Paraná UFPR This is a prospective cohort study with follow up of 6 and 24 months The aim of this study is to assess the effects of weight loss after bariatric surgery associated anthropometric characteristic metabolic changes glucose cholesterol profilehepatic enzymes Fibroblast growth factor- 21FGF-21 blood pressure the profile of adipokines proanti-inflammatory adiponectin interleukin-6 IL-6interleukin-10 IL-10 C reactive protein CRP plasminogen activator inhibitor-1 PAI-1 tumor necrosis factor alpha TNF-α intercellular adhesion molecule-1 ICAM-1 resistin frizzled-related protein 5 SFrp5 and neuroendocrine regulation of energy balance leptin neuropeptide Y NPY alpha-melanocyte stimulating hormone α-MSH melanin-concentrating hormone MCH and agouti-related peptide AgRP as well as the quality of life in obese adults
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None