Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00154921
Status:
UNKNOWN
Last Update Posted:
2005-11-23
First Post:
2005-09-09
Brief Title:
Clinical Usefulness of Optical Skin Biopsy
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Clinical Usefulness of Optical Skin Biopsy
Status:
UNKNOWN
Status Verified Date:
2004-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Traditional biopsy requires the removal fixation and staining of tissues from the human body Its procedure is invasive and painful Non-invasive in vivo optical biopsy is thus required which should provide non-invasive highly penetrative three-dimensional 3D imaging with sub-micron spatial resolution Optical biopsy based on scanning two-photon fluorescence microscopy TPFM is a good method for biopsy of skin due to its high lateral resolution low out-of-focus damage and intrinsic three-dimensional 3D section capability However current technology still presents several limitations including low penetration depth in-focus cell damages and multi-photon phototoxicity due to high optical intensity in the 800 nm wavelength region and toxicity if exogenous fluorescence markers were required We study the harmonics optical biopsy of a human skin sample using a femtosecond Crforsterite laser centered at 1230 nm Higher harmonics generation is known to leave no energy deposition to the interacted matters due to their energy-conservation characteristic This energy-conservation characteristic provides the noninvasive nature desirable for clinical imaging In our study we will evaluate the clinical applications of optical skin biopsy using harmonic generation microscopy
Detailed Description:
Traditional biopsy requires the removal fixation and staining of tissues from the human body Its procedure is invasive and painful Non-invasive in vivo optical biopsy is thus required which should provide non-invasive highly penetrative three-dimensional 3D imaging with sub-micron spatial resolution Optical biopsy based on scanning two-photon fluorescence microscopy TPFM is a good method for biopsy of skin due to its high lateral resolution low out-of-focus damage and intrinsic three-dimensional 3D section capability However current technology still presents several limitations including low penetration depth in-focus cell damages and multi-photon phototoxicity due to high optical intensity in the 800 nm wavelength region and toxicity if exogenous fluorescence markers were required We study the harmonics optical biopsy of a human skin sample using a femtosecond Crforsterite laser centered at 1230 nm Higher harmonics generation is known to leave no energy deposition to the interacted matters due to their energy-conservation characteristic This energy-conservation characteristic provides the noninvasive nature desirable for clinical imaging In our study we will evaluate the clinical applications of optical skin biopsy using harmonic generation microscopy
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NTUH-94M29 | None | None | None |