Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00156377
Status:
COMPLETED
Last Update Posted:
2010-05-25
First Post:
2005-09-08
Brief Title:
Prophylaxis With Intranasal Mupirocin for Prevention of S Aureus Infections
Sponsor:
University Hospital Muenster
Organization:
University Hospital Muenster
Study Overview
Official Title:
Investigation of the Influence of Intranasal Mupirocin on the Prevalence of S Aureus Nosocomial Infections by Eradication of Intranasal S Aureus
Status:
COMPLETED
Status Verified Date:
2005-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on subsequent Staphylococcus aureus infection a prospective randomized trial was performed particularly including patients with predisposing risk factors for S aureus infections
Detailed Description:
In a past study we showed that there is a strong correlation between strains colonizing the anterior nares strains isolated from the presumed foci of infection and strains isolated from blood in patients with Staphylococcus aureus bacteremia These results suggested that a substantial proportion of cases of systemic S aureus infections appear to be of endogenous origin and that eradication of nasal colonization should be the chief strategy for reducing the incidence of hospital-acquired S aureus infections
In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on subsequent S aureus infection a prospective randomized trial was performed particularly including patients with predisposing risk factors for S aureus infections All patients admitted to selected units in clinics for anaesthesiology hemato-oncology cardiac surgery and orthopedics at the University Hospital of Muenster were regularly screened for nasal carriage ie at admission and subsequently on a weekly basis S aureus carrying patients were prospectively randomized to be either treated with mupirocin for 5 days or left untreated Patients infected with S aureus at admission and patients detected to be MRSA carrier were excluded from randomization
Patients were regularly seen during the course of their hospital stay and predisposingconditional risk factors were systematically documented In both groups untreated patients and patients with mupirocin prophylaxis all nosocomial infections were documented according to CDC guidelines If infected specimens were taken for microbiological diagnosis All S aureus isolates from the anterior nares as well as from the focus of infection were collected and were genotyped
In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on subsequent S aureus infection a prospective randomized trial was performed particularly including patients with predisposing risk factors for S aureus infections All patients admitted to selected units in clinics for anaesthesiology hemato-oncology cardiac surgery and orthopedics at the University Hospital of Muenster were regularly screened for nasal carriage ie at admission and subsequently on a weekly basis S aureus carrying patients were prospectively randomized to be either treated with mupirocin for 5 days or left untreated Patients infected with S aureus at admission and patients detected to be MRSA carrier were excluded from randomization
Patients were regularly seen during the course of their hospital stay and predisposingconditional risk factors were systematically documented In both groups untreated patients and patients with mupirocin prophylaxis all nosocomial infections were documented according to CDC guidelines If infected specimens were taken for microbiological diagnosis All S aureus isolates from the anterior nares as well as from the focus of infection were collected and were genotyped
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None