Ignite Creation Date:
2024-05-06 @ 2:36 AM
Last Modification Date:
2024-10-26 @ 11:21 AM
Study NCT ID:
NCT02083146
Status:
TERMINATED
Last Update Posted:
2018-03-20
First Post:
2014-03-07
Brief Title:
C1qTNF-related Proteins in Coronary Artery Disease
Sponsor:
Korea University
Organization:
Korea University
Study Overview
Official Title:
C1qTNF-related Proteins in Coronary Artery Disease
Status:
TERMINATED
Status Verified Date:
2018-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Study subjects were not enrolled
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Now adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines Recently members of the C1qtumor necrosis factor-related protein CTRP family have been reported to share structural homology with adiponectin To date 15 CTRP family members have been found that might play major roles in metabolism and inflammation The investigators tried to clarify the relationship between CTRP family and coronary artery disease CAD in Korean men and women
Detailed Description:
Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease CVD Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties Hypoadiponectinemia has been associated with an increased risk of coronary artery disease CAD in several though not all studies Recently a new family of secreted proteins C1qTNF-related protein CTRP was cloned on the basis of sequence homology with adiponectin This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation Each CTRP family member has its own unique tissue expression profile and function in regulating glucose andor fat metabolism In the present study we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None