Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00155311
Status:
COMPLETED
Last Update Posted:
2013-03-15
First Post:
2005-09-08
Brief Title:
The Regulation of Osteoprotegerin by Mechanical Stimulation
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2013-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To test whether levels of OPG can be changed during orthodontic treatment Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process
Detailed Description:
Long treatment time is a major factor causing high fee for orthodontic treatment Patients would have dental caries or periodontitis resulted from improper oral hygiene care during this long treatment period Therefore how to speed up the tooth movement which determines the duration of orthodontic treatment can help more people to obtain good occlusion and esthetics Orthodontic force on tooth induces bone resorption on the compression side and bone deposition on the tension side thus bone remodels and then tooth moves Bone resorption is a complex process Osteoblasts play an important role during initiation of bone resorption
Changes OPG expression of osteoblasts under mechanical stimulation can play a role in bone remodeling In order to test this hypothesis the following specific aims will be achieved
1 To test whether levels of OPG can be changed during orthodontic treatment Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process
2 To optimize the regulation by changing magnitude and frequency of pressure and characterize the time table for these changes
Changes OPG expression of osteoblasts under mechanical stimulation can play a role in bone remodeling In order to test this hypothesis the following specific aims will be achieved
1 To test whether levels of OPG can be changed during orthodontic treatment Alveolar bone samples will be collected from partially impacted third molars after orthodontic uprighting for different period of time in volunteers In situ hybridization and immunohistochemistry analysis for OPG and RANKL will reveal their roles in this physiological process
2 To optimize the regulation by changing magnitude and frequency of pressure and characterize the time table for these changes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None