Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00152698
Status:
COMPLETED
Last Update Posted:
2023-07-12
First Post:
2005-09-08
Brief Title:
Effect of Irbesartan on Endothelial Function of the Retinal Vasculature in Patients With Hypercholesterolemia
Sponsor:
University of Erlangen-Nürnberg Medical School
Organization:
University of Erlangen-Nürnberg Medical School
Study Overview
Official Title:
A Randomised Double-blind Placebo-controlled Phase III Trial to Study the Effect of Irbesartan on Endothelial Function of the Retinal Vasculature in Patients With Hypercholesterolemia
Status:
COMPLETED
Status Verified Date:
2023-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The retinal vasculature is morphologically and functionally related to the cerebral vessels due to its common origin from the internal carotid artery A recent study demonstrated that endothelium-dependent vasodilation of the retinal vasculature is impaired in patients with essential hypertension which is a strong risk factor for stroke Furthermore AT1-receptor blockade was demonstrated to improve retinal endothelium-dependent vasodilation in these hypertensive patients Hypercholesterolemia is also a risk factor for ischemic stroke and impairment of endothelial function has been observed in various vascular beds in hypercholesterolemic patients including the coronary and the forearm vasculature Whether endothelial function of the retinal vasculature is impaired in patients with hypercholesterolemia has not yet been investigated In patients with stroke AT1-receptor blockade and angiotensin-converting enzyme inhibition have beneficial effects on clinical outcome Alterations of endothelial function of the cerebral vasculature might be one pathogenetic factor for the beneficial clinical outcome To further address this issue the present study was designed to test the hypothesis that endothelium-dependent vasodilation of the retinal vasculature is impaired in hypercholesterolemic patients and that endothelial function can be improved by AT1-receptor blockade
Detailed Description:
see above
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None