Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00158145
Status:
COMPLETED
Last Update Posted:
2017-01-10
First Post:
2005-09-08
Brief Title:
Assessing the Variability Over Time of Tobacco Carcinogen Biomarkers in Smokers - 2
Sponsor:
National Institute on Drug Abuse NIDA
Organization:
National Institute on Drug Abuse NIDA
Study Overview
Official Title:
Longitudinal Study of Prostate Lung Colon and Ovarian Cancer PLCO Screen Trial
Status:
COMPLETED
Status Verified Date:
2008-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Lung cancer is the leading cause of cancer death in the United States Currently it remains impossible to predict which smokers will get cancer Each puff of a cigarette delivers a mixture of over 60 known carcinogens Biomarkers that quantify carcinogen levels and metabolism are a useful tool and available to use The purpose of this study is to assess the variability of tobacco smoke carcinogen biomarker levels over one year in a group of smokers
Detailed Description:
Lung cancer is the leading cause of cancer death in the United States Approximately 90 of lung cancer is caused by cigarette smoking While most lung cancer cases occur in smokers or ex-smokers only 15-25 of smokers will get lung cancer Currently it remains impossible to predict which smokers will get cancer
Each puff of a cigarette delivers along with nicotine a mixture of over 60 known carcinogens Most of these carcinogens require metabolic activation before they can negatively affect cell DNA and cause cancer Biomarkers that quantify carcinogen levels and metabolic activity of carcinogens are a useful tool and available to use The purpose of this study is to assess the variability of tobacco smoke carcinogen biomarker levels over one year in a group of smokers
This longitudinal observational study will involve a repeated measure analysis of 6 different tobacco carcinogen biomarkers Fifty current smokers who intend to continue smoking for the duration of the study will be recruited through advertisements Participants will be compensated for their time Blood samples will be collected every two months for one year All samples will be analyzed for the 6 different carcinogen biomarkers and individual variability in biomarker levels will be assessed
Each puff of a cigarette delivers along with nicotine a mixture of over 60 known carcinogens Most of these carcinogens require metabolic activation before they can negatively affect cell DNA and cause cancer Biomarkers that quantify carcinogen levels and metabolic activity of carcinogens are a useful tool and available to use The purpose of this study is to assess the variability of tobacco smoke carcinogen biomarker levels over one year in a group of smokers
This longitudinal observational study will involve a repeated measure analysis of 6 different tobacco carcinogen biomarkers Fifty current smokers who intend to continue smoking for the duration of the study will be recruited through advertisements Participants will be compensated for their time Blood samples will be collected every two months for one year All samples will be analyzed for the 6 different carcinogen biomarkers and individual variability in biomarker levels will be assessed
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P50-13333-2 | None | None | None |
| DPMC | None | None | None |