Ignite Creation Date:
2024-05-05 @ 11:52 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00154466
Status:
COMPLETED
Last Update Posted:
2014-06-26
First Post:
2005-09-09
Brief Title:
Study on the Efficacy and Mechanism of Cardiac Rehabilitation for Stem Cell Mobilization and Heart Failure Improvement
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
An Association Study Between Cardiac Rehabilitation and Stem Cell Mobilization in Patients With Myocardial Infarction
Status:
COMPLETED
Status Verified Date:
2014-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
One emerging concept is that some form of injury or inflammation is a prerequisite for the success of circulating-cell participation in differentiated tissue structure and function Once reperfusion is achieved in acute myocardial infarction an intense inflammatory cascade is unleashed
The architecture of the left ventricle rearranges leading to ventricular remodeling The homing processinvolves stem cell migration to the sites of injury or ischemia which provides an environment that is favorable to growth and function This microenvironment is a stimulus for homing and differentiation of stem cells of the appropriate lineage It increases vascular permeability and expression of adhesion proteins like integrin along with homing receptors that facilitate the attachment which is mediated by cell-to-cell contact and chemoattractant release from local tissue injuryThe migratory capacity of stem cells might be dependent on natural growth factors such as vascular endothelial growth factor VEGF stromal cell-derived factor-1 SDF-1and stem cell factor SCFThe expression of VEGF SDF-1 and SCF is highly up-regulated in hypoxic tissue supporting the hypothesis that these factors may represent homing signals crucial to the recruitment of circulating progenitor cells to assist the endogenous repair mechanisms in the infarcted tissue This study will examine whether cardiac rehabilitation increases the concentration of stem cell factors released into the bloodstream and if these factors are correlated with the improvement of heart function
The architecture of the left ventricle rearranges leading to ventricular remodeling The homing processinvolves stem cell migration to the sites of injury or ischemia which provides an environment that is favorable to growth and function This microenvironment is a stimulus for homing and differentiation of stem cells of the appropriate lineage It increases vascular permeability and expression of adhesion proteins like integrin along with homing receptors that facilitate the attachment which is mediated by cell-to-cell contact and chemoattractant release from local tissue injuryThe migratory capacity of stem cells might be dependent on natural growth factors such as vascular endothelial growth factor VEGF stromal cell-derived factor-1 SDF-1and stem cell factor SCFThe expression of VEGF SDF-1 and SCF is highly up-regulated in hypoxic tissue supporting the hypothesis that these factors may represent homing signals crucial to the recruitment of circulating progenitor cells to assist the endogenous repair mechanisms in the infarcted tissue This study will examine whether cardiac rehabilitation increases the concentration of stem cell factors released into the bloodstream and if these factors are correlated with the improvement of heart function
Detailed Description:
Exercise training has beneficial hemodynamic effects in patients with congestive heart failureA similar benefit may be seen after MI with an improvement in functional capacity averaging 20 percent More important however is the possible effect on survival In a meta-analysis of 24 trials examining the effect of cardiac rehabilitation after MI there was a significant reduction in mortality with rehabilitation odds ratio 081
Previous studies focused on the effect of rehabilitation comes from the improvement of oxygen utilization in skeletal muscle The effects on cardiac morphology and perfusion status were rather little to be addressed
In this study we will collect the questionaires blood sampling for assay of stem cell factors maximal O2 consumption and cardiac MRI before and after cardiac rehabilitationSDF-1 stromal cell derived factor-1 SCFstem cell factor and VEGF vasculoendothelial growth factor will be measured by ELISA Cardiac MRI will provide the information about 1 LV function 2 scar size and 3 perfusion status dipyridamole stress MRI
Previous studies focused on the effect of rehabilitation comes from the improvement of oxygen utilization in skeletal muscle The effects on cardiac morphology and perfusion status were rather little to be addressed
In this study we will collect the questionaires blood sampling for assay of stem cell factors maximal O2 consumption and cardiac MRI before and after cardiac rehabilitationSDF-1 stromal cell derived factor-1 SCFstem cell factor and VEGF vasculoendothelial growth factor will be measured by ELISA Cardiac MRI will provide the information about 1 LV function 2 scar size and 3 perfusion status dipyridamole stress MRI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None