Ignite Creation Date:
2024-05-06 @ 2:29 AM
Last Modification Date:
2024-10-26 @ 11:19 AM
Study NCT ID:
NCT02057497
Status:
WITHDRAWN
Last Update Posted:
2017-10-20
First Post:
2014-02-04
Brief Title:
An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms
Sponsor:
Profil Institut für Stoffwechselforschung GmbH
Organization:
Profil Institut für Stoffwechselforschung GmbH
Study Overview
Official Title:
An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms Related to GPCR Dependent Signalling and the FTO Gene in Healthy Volunteers and in Patients With Diabetes
Status:
WITHDRAWN
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
It has been decided by the Sponsor not to conduct the trial
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
G guanine nucleotide binding proteins associating with G protein-coupled receptors GPCR are key players in the pathogenesis of obesity and diabetes and are targets of pharmacotherapeutic inter-ventions In addition G proteins binding to GPCRs either directly or permissively determine the efficacy of lifestyle interventions and drugs aiming at weight management and diabetes treatment Polymor-phisms of the fat mass and obesity-related protein FTO gene have been also well characterised and linked to energy intake body fat mass as well as CVD risk and the susceptibility to weight-reducing interventions Stratifying patients according to G protein and FTO-related genotyping may enable a more accurate prediction of individual disease courses and responses to therapeutic interventions in terms of safety and tolerability as well as efficacy Although the objectives primarily refer to the analysis of G pro-tein and FTO-related genotypes also other genes of potential relevance for the evolution of obesity and or diabetes and the response to lifestyle and pharmacological interventions may be analysed
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None