Ignite Creation Date:
2024-05-06 @ 2:29 AM
Last Modification Date:
2024-10-26 @ 11:19 AM
Study NCT ID:
NCT02057354
Status:
COMPLETED
Last Update Posted:
2018-04-25
First Post:
2014-02-05
Brief Title:
Neuroimaging Study of Exercise and Memory Function
Sponsor:
Boston University
Organization:
Boston University
Study Overview
Official Title:
Aerobic Exercise Neurotrophins and fMRI of Hippocampal Function and Structure
Status:
COMPLETED
Status Verified Date:
2018-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
EMF
Brief Summary:
The investigators are examining the effects of exercise and cardiovascular fitness on cognitive processes brain function and the amount of several proteins in the blood These proteins include a hormone called cortisol also known as the stress hormone and a growth factor called brain-derived neurotrophic factor BDNF The stress hormone cortisol is produced by the adrenal glands Stress exercise obesity and other factors may influence cortisol levels BDNF is a protein that promotes the health of nerve cells in the brain and in the body It plays a role in the growth maturation and maintenance of these cells The amount of this protein in blood samples is therefore an indicator of healthy nerve cell function Here the investigators are investigating if exercise improves brain function by changing BDNF levels Participation in this research study will take approximately 4 months During this time participants will make four initial study visits The first visit is for informed consent and screening the second and third visits are for baseline fitness testing and the fourth visit is for a blood draw cognitive testing and a functional Magnetic Resonance Imaging fMRI exam Functional MRI is a brain imaging technique that uses a magnetic field to take pictures of the brain while a person performs a given task It will take up to approximately three weeks to complete these initial four study visits Following the four initial study visits the exercise-training program will begin Participants will be randomized to one of two training programs an aerobic exercise program and a non-aerobic exercise program consisting of strengthening balance and stretching exercises The exercise training program will last 12 weeks There will be three one-hour exercise sessions per week After completion of the exercise-training program participants will attend three follow-up study visits The first two follow-up visits are for fitness testing The third and final follow-up visit is for a blood draw cognitive testing and an MRI exam
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R00AG036845 | NIH | None | httpsreporternihgovquickSearchR00AG036845 |