Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00150527
Status:
COMPLETED
Last Update Posted:
2009-02-05
First Post:
2005-09-06
Brief Title:
Specific Effects of Escitalopram on Neuroendocrine Response
Sponsor:
Queens University
Organization:
Queens University
Study Overview
Official Title:
Specific Effects of Escitalopram on Neuroendocrine Response
Status:
COMPLETED
Status Verified Date:
2009-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Citalopram a selective serotonin reuptake inhibitor SSRI is used as a neuroendocrine probe in human subjects to assess serotonin 5-hydroxytryptamine 5-HT function as reflected in prolactin and plasma cortisol release Citalopram is a racemic mixture of equal parts of the S and R- enantiomers The S form escitalopram has been identified as being the active isomer and inhibitor of serotonin reuptake and consequently antidepressant activity is associated almost exclusively with the S-enantiomer Escitalopram has been shown to be approximately twice as potent as citalopram at the primary high-affinity binding site on the human serotonin transporter Interestingly investigations have suggested an antagonistic interaction of the R- and S-enantiomer at an allosteric binding site on the serotonin transporter This antagonism has been shown in animal studies where the addition of R-citalopram to escitalopram treatments significantly counteracts the antidepressant and anti-anxiolytic effects of escitalopram From these clinical and experimental data the researchers can anticipate that escitalopram would increase cortisol and prolactin in the neuroendocrine challenge paradigm more effectively than citalopram
Detailed Description:
See above
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None