Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:14 AM
Study NCT ID:
NCT00152074
Status:
COMPLETED
Last Update Posted:
2015-06-09
First Post:
2005-09-08
Brief Title:
Salt Reduction on Blood Pressure and Cardiovascular Organ Damage
Sponsor:
St Georges University of London
Organization:
St Georges University of London
Study Overview
Official Title:
Effects of Modest Salt Reduction on Blood Pressure and Markers of Target Organ Damage in Patients With Untreated Essential Hypertension or Prehypertension
Status:
COMPLETED
Status Verified Date:
2006-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to determine the effect of a modest reduction in salt intake on blood pressure in white black and Asian individuals with hypertension or prehypertension and also to determine whether a modest reduction in salt intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease
Detailed Description:
The average salt intake for adults in the UK is approximately 10-12 gday The current recommendations are to reduce salt intake to 5-6 gday or less Many randomised trials have shown that this reduction in salt intake has a significant effect on blood pressure however most previous trials were carried out in white individuals fewer in blacks and none in Asians
Increasing evidence from epidemiological studies in humans and experimental studies in animals suggest that that our current high salt intake may have other harmful effects on cardiovascular health eg a direct effect on stroke left ventricular hypertrophy progression of renal disease and proteinuria independent of and additive to salts effect on blood pressure However no well-controlled trials have studied whether a modest reduction in salt intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease
We propose to carry out a double-blind randomised trial to study the effects of a modest reduction in salt intake as currently recommended on blood pressure and target organ damage assessed by the measurements of 24 hour urinary albumin excretion left ventricular mass left ventricular diastolic function pulse wave velocity and capillary density in white black and Asian individuals with hypertension or prehypertension
Comparisons Usual salt intake compared to reduced salt intake
Increasing evidence from epidemiological studies in humans and experimental studies in animals suggest that that our current high salt intake may have other harmful effects on cardiovascular health eg a direct effect on stroke left ventricular hypertrophy progression of renal disease and proteinuria independent of and additive to salts effect on blood pressure However no well-controlled trials have studied whether a modest reduction in salt intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease
We propose to carry out a double-blind randomised trial to study the effects of a modest reduction in salt intake as currently recommended on blood pressure and target organ damage assessed by the measurements of 24 hour urinary albumin excretion left ventricular mass left ventricular diastolic function pulse wave velocity and capillary density in white black and Asian individuals with hypertension or prehypertension
Comparisons Usual salt intake compared to reduced salt intake
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| N02034 | None | None | None |