Ignite Creation Date:
2024-05-06 @ 2:22 AM
Last Modification Date:
2024-10-26 @ 11:17 AM
Study NCT ID:
NCT02027506
Status:
UNKNOWN
Last Update Posted:
2014-01-06
First Post:
2014-01-03
Brief Title:
Diagnostic Value of Electrocardiographic St-t Wave Changes in Patients With Chronic Stable Angina
Sponsor:
Alexandria University
Organization:
Alexandria University
Study Overview
Official Title:
DIAGNOSTIC VALUE OF ELECTROCARDIOGRAPHIC ST-T WAVE CHANGES IN LEAD aVL IN PATIENTS WITH CHRONIC STABLE ANGINA
Status:
UNKNOWN
Status Verified Date:
2014-01
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
ECG
Brief Summary:
The electrocardiogram ECG is a simple and non-invasive bedside diagnostic tool with a well-established role in the diagnosis of CAD Many studies have found that the admission of ECG provides important prognostic information in patients admitted with chest pain For instance T wave inversion in anterior or inferior location and or ST-segment depression has been associated with high incidence of CAD
Detailed Description:
The aim of the work will be directed to study the diagnostic value of electrocardiographic ST-T wave changes in lead aVL in patients with chronic stable angina
The ECG findings vary considerably depending importantly on four major factors 1 the duration of the ischemic process acute versus evolving or chronic 2 its extent large versus small 3 its topography anterior versus inferior-posterior and right ventricular 4 the presence of other underlying conditions eg LBBB WPW or pacemaker pattern that can mask or alters the classic pattern
The resting electrocardiogram is normal in approximately half of patients with chronic stable angina pectoris and even patients with severe CAD may have a normal tracing at rest A normal resting ECG suggesting a normal LV function and it is unusual finding in a patient with an extensive previous infarction
The most common electrocardiographic abnormalities in patients with chronic CAD are non specific ST-Twave changes with or without abnormal Q waves In addition to myocardial ischemia other conditions that can produce ST-T wave abnormalities include LV hypertrophy or dilation electrolyte abnormalities neurogenic effects and anti-arrhythmic drugs
In patients with known CAD however the occurrence of ST-T wave abnormalities on the resting ECG may correlate with the severity of the underlying heart disease This association may explain the adverse association of ST-Twave changes with prognosis of these patients In contrast a normal resting ECG is more favorable long-term prognostic sign in patients with suspected or definite CAD
The ECG findings vary considerably depending importantly on four major factors 1 the duration of the ischemic process acute versus evolving or chronic 2 its extent large versus small 3 its topography anterior versus inferior-posterior and right ventricular 4 the presence of other underlying conditions eg LBBB WPW or pacemaker pattern that can mask or alters the classic pattern
The resting electrocardiogram is normal in approximately half of patients with chronic stable angina pectoris and even patients with severe CAD may have a normal tracing at rest A normal resting ECG suggesting a normal LV function and it is unusual finding in a patient with an extensive previous infarction
The most common electrocardiographic abnormalities in patients with chronic CAD are non specific ST-Twave changes with or without abnormal Q waves In addition to myocardial ischemia other conditions that can produce ST-T wave abnormalities include LV hypertrophy or dilation electrolyte abnormalities neurogenic effects and anti-arrhythmic drugs
In patients with known CAD however the occurrence of ST-T wave abnormalities on the resting ECG may correlate with the severity of the underlying heart disease This association may explain the adverse association of ST-Twave changes with prognosis of these patients In contrast a normal resting ECG is more favorable long-term prognostic sign in patients with suspected or definite CAD
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None