Ignite Creation Date:
2024-05-06 @ 2:22 AM
Last Modification Date:
2024-10-26 @ 11:17 AM
Study NCT ID:
NCT02022436
Status:
COMPLETED
Last Update Posted:
2023-11-13
First Post:
2013-12-12
Brief Title:
Evaluation of Predictors of Aortic Aneurysm Growth and Rupture
Sponsor:
Rabih A Chaer
Organization:
University of Pittsburgh
Study Overview
Official Title:
Aortic Wall Behavior as a Predictor of Aortic Aneurysm Growth and Rupture
Status:
COMPLETED
Status Verified Date:
2023-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal is to non-invasively study the metabolic processes within the aortic wall that are thought to explain progression to clinical manifestations of an aortic aneurysm
Hypothesis is that the non-invasive imaging of Abdominal Aortic Aneurysm AAA with contrast ultrasound coupled with serum biomarker measurements will allow the identification of the vulnerable aortic wall and patients who are at risk of AAA growth or rupture
Hypothesis is that the non-invasive imaging of Abdominal Aortic Aneurysm AAA with contrast ultrasound coupled with serum biomarker measurements will allow the identification of the vulnerable aortic wall and patients who are at risk of AAA growth or rupture
Detailed Description:
Aim1 Prospective Contrast Ultrasound CUS imaging of patients with AAA to predict AAA growth and test gender differences in rate of growth and rupture
Aim2 Serum biomarker testing of patient with AAA CUS findings will be correlated with serum biomarkers and AAA wall histology
Prospective Contrast Ultrasound imaging of patients with AAA as part of a pilot feasibility study to predict AAA growth and test gender differences in rate of growth and rupture CUS findings will be correlated with serum biomarkers and AAA wall histology Potential significance This study will evaluate the AAA wall and will be based on detecting areas of increased vasa vasorum density within the aneurysm wall and intraluminal thrombus which indicate regional ischemia and inflammation of the aortic wall and propensity for weakening enlargement or rupture This novel evaluation of the aortic wall in patients with AAA will allow individualized treatment based on the biological potential for growth and rupture
Aim2 Serum biomarker testing of patient with AAA CUS findings will be correlated with serum biomarkers and AAA wall histology
Prospective Contrast Ultrasound imaging of patients with AAA as part of a pilot feasibility study to predict AAA growth and test gender differences in rate of growth and rupture CUS findings will be correlated with serum biomarkers and AAA wall histology Potential significance This study will evaluate the AAA wall and will be based on detecting areas of increased vasa vasorum density within the aneurysm wall and intraluminal thrombus which indicate regional ischemia and inflammation of the aortic wall and propensity for weakening enlargement or rupture This novel evaluation of the aortic wall in patients with AAA will allow individualized treatment based on the biological potential for growth and rupture
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
True
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R03AG042352-01 | NIH | None | httpsreporternihgovquickSearch1R03AG042352-01 |