Ignite Creation Date:
2024-05-06 @ 2:21 AM
Last Modification Date:
2024-10-26 @ 11:17 AM
Study NCT ID:
NCT02028975
Status:
UNKNOWN
Last Update Posted:
2014-01-07
First Post:
2013-12-18
Brief Title:
Search for Biological Markers of Orosensory Perception of Fatty Acids in Healthy Subjects and Possible Modifications in Patients With Type 2 Diabetes and in Obese Non-diabetic Patients
Sponsor:
Centre Hospitalier Universitaire Dijon
Organization:
Centre Hospitalier Universitaire Dijon
Study Overview
Official Title:
Search for Biological Markers of Orosensory Perception of Fatty Acids in Healthy Subjects and Possible Modifications in Patients With Type 2 Diabetes and in Obese Non-diabetic Patients
Status:
UNKNOWN
Status Verified Date:
2012-07
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Animal studies have shown that stimulation of the lingual lipid-receptor CD 36 is accompanied by the rapid secretion of hormones in the digestive tract incretines We aim to determine in healthy humans whether the orosensory perception of fatty acids is followed by a modification in plasma levels of digestive tract hormones cholecystokinin GIP GLP-1 secretin pancreatic peptide peptide YY insulin and metabolic markers from adipose tissue leptin ghrelin adiponectin
We also aim to determine whether the hormonal response induced by orosensory stimulation by lipids is modified
in patients with type 2 diabetes
in obese non-diabetic patients We expect to show an increase in biological markers biological and more particularly in certain digestive hormones such as Pancreatic polypeptide GIP GLP-1after stimulation of the lingual lipid receptor CD36 We will also determine whether or not this response is modified in patients with type 2 diabetes and in obese non-diabetic patients
We also wish to measure the subjects gustatory detection threshold for a fatty acid linoleic acid and to determine whether there is a relationship between the orosensory perception threshold for linoleic acid and the physiological status of the subjects In order to achieve this the thresholds for healthy subjects will be compared with thresholds for obese and diabetic subjects Expected results the threshold of detection for linoleic acid in healthy subjects will be lower than that in obese or diabetic patients
We also aim to determine whether the hormonal response induced by orosensory stimulation by lipids is modified
in patients with type 2 diabetes
in obese non-diabetic patients We expect to show an increase in biological markers biological and more particularly in certain digestive hormones such as Pancreatic polypeptide GIP GLP-1after stimulation of the lingual lipid receptor CD36 We will also determine whether or not this response is modified in patients with type 2 diabetes and in obese non-diabetic patients
We also wish to measure the subjects gustatory detection threshold for a fatty acid linoleic acid and to determine whether there is a relationship between the orosensory perception threshold for linoleic acid and the physiological status of the subjects In order to achieve this the thresholds for healthy subjects will be compared with thresholds for obese and diabetic subjects Expected results the threshold of detection for linoleic acid in healthy subjects will be lower than that in obese or diabetic patients
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None