Ignite Creation Date:
2024-05-05 @ 11:51 AM
Last Modification Date:
2024-10-26 @ 9:15 AM
Study NCT ID:
NCT00156169
Status:
COMPLETED
Last Update Posted:
2009-08-12
First Post:
2005-09-08
Brief Title:
The Effect of the Alga Dunaliella Bardawil as a Source of 9-cis Retinoic Acid on Lipid Profile in Fibrate Treated Patients
Sponsor:
Sheba Medical Center
Organization:
Sheba Medical Center
Study Overview
Official Title:
The Effect of the Alga Dunaliella Bardawil as a Source of 9-cis Retinoic Acid
Status:
COMPLETED
Status Verified Date:
2009-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The effect of fibrates on high density lipoprotein HDL-cholesterol levels is suggested to be mediated by its binding to peroxisome proliferator-activated receptor-g PPARg Upon ligand binding PPARg heterodimerizes with the 9-cis retinoic acid receptor RXR and the heterodimer regulates gene expression We assessed the hypothesis that a dual treatment with fibrate plus 9-cis b-carotene-rich powder of the alga Dunaliella bardawil as a source of 9-cis retinoic acid would improve the drugs effect on HDL-cholesterol levels
patients with plasma HDL-cholesterol levels below 40 mgdl and triglyceride TG levels above 200 mgdl after fibrate treatment for at least 6 weeks are given four capsules of Dunaliella providing 60 mg b-caroteneday The all-trans to 9-cis b-carotene ratio in the capsules is about 11
patients with plasma HDL-cholesterol levels below 40 mgdl and triglyceride TG levels above 200 mgdl after fibrate treatment for at least 6 weeks are given four capsules of Dunaliella providing 60 mg b-caroteneday The all-trans to 9-cis b-carotene ratio in the capsules is about 11
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None